diff --git a/CHANGELOG.md b/CHANGELOG.md
index a9c36a1..bf36141 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,9 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## [dev] (MM/DD/YYYY)
 
+### Added
+* Added support for ISA constants `"avx10"` and `"avx512_e5"` and CNR constants `"avx10"` and `"avx10,strict"` [gh-175](https://github.com/IntelPython/mkl-service/pull/175)
+
 ### Removed
 * Dropped support for Python 3.9 [gh-118](https://github.com/IntelPython/mkl-service/pull/118)
 * Dropped support for `"ssse3"`, `"sse4_1"`, `"avx"`, `"avx512_mic"`, `"avx512_mic,strict"`, and `"avx512_mic_e1"` cbwr branches [gh-173](https://github.com/IntelPython/mkl-service/pull/173)
diff --git a/mkl/_mkl_service.pxd b/mkl/_mkl_service.pxd
index ea22e1c..7319339 100644
--- a/mkl/_mkl_service.pxd
+++ b/mkl/_mkl_service.pxd
@@ -59,6 +59,7 @@ cdef extern from "mkl.h":
     int MKL_CBWR_AVX2
     int MKL_CBWR_AVX512
     int MKL_CBWR_AVX512_E1
+    int MKL_CBWR_AVX10
 
     int MKL_CBWR_SUCCESS
     int MKL_CBWR_ERR_INVALID_SETTINGS
@@ -73,10 +74,12 @@ cdef extern from "mkl.h":
     int MKL_ENABLE_AVX512_E3
     int MKL_ENABLE_AVX512_E4
     int MKL_ENABLE_AVX512_E1
+    int MKL_ENABLE_AVX512_E5
     int MKL_ENABLE_AVX512
     int MKL_ENABLE_AVX2
     int MKL_ENABLE_AVX2_E1
     int MKL_ENABLE_SSE4_2
+    int MKL_ENABLE_AVX10
 
     # MPI Implementation Constants
     int MKL_BLACS_CUSTOM
diff --git a/mkl/_mkl_service.pyx b/mkl/_mkl_service.pyx
index 3b59b08..710bd8f 100644
--- a/mkl/_mkl_service.pyx
+++ b/mkl/_mkl_service.pyx
@@ -684,6 +684,8 @@ cdef object __cbwr_set(branch=None) except *:
             "avx512,strict": mkl.MKL_CBWR_AVX512 | mkl.MKL_CBWR_STRICT,
             "avx512_e1": mkl.MKL_CBWR_AVX512_E1,
             "avx512_e1,strict": mkl.MKL_CBWR_AVX512_E1 | mkl.MKL_CBWR_STRICT,
+            "avx10": mkl.MKL_CBWR_AVX10,
+            "avx10,strict": mkl.MKL_CBWR_AVX10 | mkl.MKL_CBWR_STRICT,
         },
         "output": {
             mkl.MKL_CBWR_SUCCESS: "success",
@@ -721,6 +723,8 @@ cdef inline __cbwr_get(cnr_const=None) except *:
             mkl.MKL_CBWR_AVX512 | mkl.MKL_CBWR_STRICT: "avx512,strict",
             mkl.MKL_CBWR_AVX512_E1: "avx512_e1",
             mkl.MKL_CBWR_AVX512_E1 | mkl.MKL_CBWR_STRICT: "avx512_e1,strict",
+            mkl.MKL_CBWR_AVX10: "avx10",
+            mkl.MKL_CBWR_AVX10 | mkl.MKL_CBWR_STRICT: "avx10,strict",
             mkl.MKL_CBWR_ERR_INVALID_INPUT: "err_invalid_input",
         },
     }
@@ -749,6 +753,8 @@ cdef object __cbwr_get_auto_branch() except *:
             mkl.MKL_CBWR_AVX512 | mkl.MKL_CBWR_STRICT: "avx512,strict",
             mkl.MKL_CBWR_AVX512_E1: "avx512_e1",
             mkl.MKL_CBWR_AVX512_E1 | mkl.MKL_CBWR_STRICT: "avx512_e1,strict",
+            mkl.MKL_CBWR_AVX10: "avx10",
+            mkl.MKL_CBWR_AVX10 | mkl.MKL_CBWR_STRICT: "avx10,strict",
             mkl.MKL_CBWR_SUCCESS: "success",
             mkl.MKL_CBWR_ERR_INVALID_INPUT: "err_invalid_input",
         },
@@ -773,10 +779,12 @@ cdef object __enable_instructions(isa=None) except *:
             "avx512_e3": mkl.MKL_ENABLE_AVX512_E3,
             "avx512_e2": mkl.MKL_ENABLE_AVX512_E2,
             "avx512_e1": mkl.MKL_ENABLE_AVX512_E1,
+            "avx512_e5": mkl.MKL_ENABLE_AVX512_E5,
             "avx512": mkl.MKL_ENABLE_AVX512,
             "avx2_e1": mkl.MKL_ENABLE_AVX2_E1,
             "avx2": mkl.MKL_ENABLE_AVX2,
             "sse4_2": mkl.MKL_ENABLE_SSE4_2,
+            "avx10": mkl.MKL_ENABLE_AVX10,
         },
     }
     cdef int c_mkl_isa = __mkl_str_to_int(isa, __variables["input"])
diff --git a/mkl/tests/test_mkl_service.py b/mkl/tests/test_mkl_service.py
index 7c9c97a..0080ae6 100644
--- a/mkl/tests/test_mkl_service.py
+++ b/mkl/tests/test_mkl_service.py
@@ -223,6 +223,7 @@ def check_cbwr(branch, cnr_const):
     "avx2",
     "avx512",
     "avx512_e1",
+    "avx10",
 ]
 
 
@@ -230,6 +231,7 @@ def check_cbwr(branch, cnr_const):
     "avx2,strict",
     "avx512,strict",
     "avx512_e1,strict",
+    "avx10,strict",
 ]
 
 
@@ -247,16 +249,24 @@ def test_cbwr_get_auto_branch():
     mkl.cbwr_get_auto_branch()
 
 
-def test_enable_instructions_avx512():
-    mkl.enable_instructions("avx512")
-
-
-def test_enable_instructions_avx2():
-    mkl.enable_instructions("avx2")
+instructions = [
+    "single_path",
+    "avx512_e4",
+    "avx512_e3",
+    "avx512_e2",
+    "avx512_e1",
+    "avx512_e5",
+    "avx512",
+    "avx2_e1",
+    "avx2",
+    "sse4_2",
+    "avx10",
+]
 
 
-def test_enable_instructions_sse4_2():
-    mkl.enable_instructions("sse4_2")
+@pytest.mark.parametrize("isa", instructions)
+def test_enable_instructions(isa):
+    mkl.enable_instructions(isa)
 
 
 def test_set_env_mode():