From 58bcf587e5a05239ff7c5f96348de62d3077f4ad Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Tue, 17 Mar 2026 00:49:23 +0100 Subject: [PATCH 01/13] feat: add evaluation callbacks, metrics and analysis --- configs/default.yaml | 25 +- stain_normalization/analysis/__init__.py | 6 + stain_normalization/analysis/analyzer.py | 209 +++++++++++++++++ stain_normalization/callbacks/__init__.py | 7 + stain_normalization/callbacks/_base.py | 32 +++ .../callbacks/analysis_export.py | 58 +++++ stain_normalization/callbacks/tiles_export.py | 85 +++++++ .../callbacks/wsi_assembler.py | 217 ++++++++++++++++++ stain_normalization/metrics/__init__.py | 16 ++ stain_normalization/metrics/image_metrics.py | 62 +++++ stain_normalization/metrics/vector_metrics.py | 75 ++++++ 11 files changed, 790 insertions(+), 2 deletions(-) create mode 100644 stain_normalization/analysis/__init__.py create mode 100644 stain_normalization/analysis/analyzer.py create mode 100644 stain_normalization/callbacks/__init__.py create mode 100644 stain_normalization/callbacks/_base.py create mode 100644 stain_normalization/callbacks/analysis_export.py create mode 100644 stain_normalization/callbacks/tiles_export.py create mode 100644 stain_normalization/callbacks/wsi_assembler.py create mode 100644 stain_normalization/metrics/__init__.py create mode 100644 stain_normalization/metrics/image_metrics.py create mode 100644 stain_normalization/metrics/vector_metrics.py diff --git a/configs/default.yaml b/configs/default.yaml index 8b57808..f2f8c4b 100644 --- a/configs/default.yaml +++ b/configs/default.yaml @@ -20,6 +20,23 @@ callbacks: monitor: validation/loss mode: min + tiles_export: + _target_: stain_normalization.callbacks.TilesExport + output_dir: ${output_dir} + normalization_config: ${data.test.normalize} + n_first: 10 + sample_rate: 0.0005 # for test dataset cca 100 tiles + + analysis_export: + _target_: stain_normalization.callbacks.AnalysisExport + output_dir: ${output_dir} + normalization_config: ${data.test.normalize} + + wsi_assembler: + _target_: stain_normalization.callbacks.WSIAssembler + output_dir: ${output_dir} + normalization_config: ${data.predict.normalize} + early_stopping: _target_: lightning.pytorch.callbacks.EarlyStopping monitor: validation/loss @@ -42,15 +59,19 @@ trainer: callbacks: - ${callbacks.model_checkpoint} - ${callbacks.early_stopping} + - ${callbacks.analysis_export} data: batch_size: 64 num_workers: 8 - + metadata: user: ??? experiment_name: Stain-Normalization - run_name: ??? + run_name: ??? description: ??? hyperparams: ${model} + +output_dir: ??? # ./data/outputs + diff --git a/stain_normalization/analysis/__init__.py b/stain_normalization/analysis/__init__.py new file mode 100644 index 0000000..16504d5 --- /dev/null +++ b/stain_normalization/analysis/__init__.py @@ -0,0 +1,6 @@ +from stain_normalization.analysis.analyzer import StainAnalyzer + + +__all__ = [ + "StainAnalyzer", +] diff --git a/stain_normalization/analysis/analyzer.py b/stain_normalization/analysis/analyzer.py new file mode 100644 index 0000000..05f2a8f --- /dev/null +++ b/stain_normalization/analysis/analyzer.py @@ -0,0 +1,209 @@ +"""Stain normalization analysis tool. + +Compares images using selected metrics, accumulates results, +and provides statistics and saving. +""" + +from pathlib import Path +from typing import Any, ClassVar + +import numpy as np +import pandas as pd +from rationai.staining import estimate_stain_vectors +from skimage.metrics import structural_similarity + +from stain_normalization.metrics.image_metrics import ( + compute_lab_brightness_psnr, + compute_nmi, + compute_pcc, +) +from stain_normalization.metrics.vector_metrics import compare_vectors + + +class StainAnalyzer: + """Compare images using selected metrics, accumulate results. + + Args: + reference: Optional fixed reference image. If given, stain vectors + and NMI are pre-computed once. + metrics: Which metrics to compute. None = all. + """ + + AVAILABLE_METRICS: ClassVar[list[str]] = [ + "vectors", + "ssim", + "pcc", + "nmi", + "lab_psnr", + ] + PAIRED_ONLY: ClassVar[set[str]] = {"ssim", "pcc", "lab_psnr"} + + def __init__( + self, + reference: np.ndarray[Any, Any] | None = None, + metrics: list[str] | None = None, + ) -> None: + self.metrics = metrics or self.AVAILABLE_METRICS + self._results: list[dict[str, Any]] = [] + + for m in self.metrics: + if m not in self.AVAILABLE_METRICS: + raise ValueError( + f"Unknown metric '{m}'. Available: {self.AVAILABLE_METRICS}" + ) + + # if we have reference image, precompute stain vectors and NMI + self._ref_img = reference + self._ref_vectors = None + self._ref_nmi = None + + if reference is not None: + if "vectors" in self.metrics: + self._ref_vectors = estimate_stain_vectors(reference) + if "nmi" in self.metrics: + self._ref_nmi = compute_nmi(reference) + + @property + def results(self) -> pd.DataFrame: + """Accumulated comparison results as DataFrame.""" + return pd.DataFrame(self._results) + + def clear(self) -> None: + """Clear accumulated results.""" + self._results.clear() + + def compare( + self, + image: np.ndarray[Any, Any], + image_id: str | None = None, + reference: np.ndarray[Any, Any] | None = None, + ) -> dict[str, Any]: + """Compare an image against the reference and store the result. + + Args: + image: Image to compare. + image_id: Optional identifier for this comparison. + reference: Override reference image for this call. + + Returns: + Dict with metric results. + """ + ref_img = reference if reference is not None else self._ref_img + if ref_img is None: + raise ValueError( + "No reference image. Pass one to __init__ or to compare()." + ) + + is_paired = reference is not None + + if reference is not None: + ref_vectors = ( + estimate_stain_vectors(ref_img) if "vectors" in self.metrics else None + ) + ref_nmi = compute_nmi(ref_img) if "nmi" in self.metrics else None + else: + ref_vectors = self._ref_vectors + ref_nmi = self._ref_nmi + + result: dict[str, Any] = {"id": image_id} if image_id is not None else {} + + if "vectors" in self.metrics: + assert ( + ref_vectors is not None + ) # fails if reference has too much background and no valid stain vectors + img_vectors = estimate_stain_vectors(image) + vec_result = compare_vectors(ref_vectors, img_vectors) + result.update(vec_result) + img_vectors_paired = ( + img_vectors[[1, 0]] if vec_result["was_swapped"] else img_vectors + ) + for j, val in enumerate(ref_vectors.flatten()): + result[f"ref_vec_{j}"] = float(val) + for j, val in enumerate(img_vectors_paired.flatten()): + result[f"img_vec_{j}"] = float(val) + + if "ssim" in self.metrics and is_paired: + result["ssim"] = float( + structural_similarity( + ref_img, + image, + channel_axis=-1, + data_range=255, + ) + ) + + if "pcc" in self.metrics and is_paired: + result["pcc"] = compute_pcc(ref_img, image) + + if "nmi" in self.metrics: + assert ref_nmi is not None + img_nmi = compute_nmi(image) + result["ref_nmi"] = ref_nmi + result["nmi"] = img_nmi + result["nmi_diff"] = img_nmi - ref_nmi + + if "lab_psnr" in self.metrics and is_paired: + result["lab_brightness_psnr"] = compute_lab_brightness_psnr(ref_img, image) + + self._results.append(result) + return result + + # --- Statistics --- + + def get_statistics(self) -> pd.DataFrame: + """Summary statistics for accumulated results. + + Returns: + DataFrame with mean, std, min, max, percentiles. + """ + df = self.results + numeric_cols = df.select_dtypes(include=[np.number]).columns + return df[numeric_cols].describe(percentiles=[0.05, 0.25, 0.5, 0.75, 0.95]) + + def get_baseline_ranges( + self, + percentile_low: float = 5, + percentile_high: float = 95, + ) -> dict[str, tuple[float, float]]: + """Get acceptable value ranges for each metric. + + Args: + percentile_low: Lower percentile bound. Defaults to 5. + percentile_high: Upper percentile bound. Defaults to 95. + + Returns: + Dict mapping metric names to (low, high) tuples. + """ + df = self.results + numeric_cols = df.select_dtypes(include=[np.number]).columns + return { + col: ( + float(df[col].quantile(percentile_low / 100)), + float(df[col].quantile(percentile_high / 100)), + ) + for col in numeric_cols + } + + def save_csv(self, output_dir: str | Path) -> Path: + """Save accumulated results and statistics as CSV files. + + Args: + output_dir: Directory to save files into. + + Returns: + Path to the output directory. + """ + output_dir = Path(output_dir) + output_dir.mkdir(parents=True, exist_ok=True) + + self.results.to_csv(output_dir / "results.csv", index=True) + self.get_statistics().to_csv(output_dir / "statistics.csv") + + ranges = self.get_baseline_ranges() + with open(output_dir / "baseline_ranges.txt", "w") as f: + f.write("Baseline Metric Ranges (5th-95th percentile)\n") + f.write("=" * 55 + "\n\n") + for metric, (low, high) in sorted(ranges.items()): + f.write(f"{metric:30s}: [{low:8.4f}, {high:8.4f}]\n") + + return output_dir diff --git a/stain_normalization/callbacks/__init__.py b/stain_normalization/callbacks/__init__.py new file mode 100644 index 0000000..4aeaf95 --- /dev/null +++ b/stain_normalization/callbacks/__init__.py @@ -0,0 +1,7 @@ +from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.callbacks.analysis_export import AnalysisExport +from stain_normalization.callbacks.tiles_export import TilesExport +from stain_normalization.callbacks.wsi_assembler import WSIAssembler + + +__all__ = ["AnalysisExport", "NormalizationCallback", "TilesExport", "WSIAssembler"] diff --git a/stain_normalization/callbacks/_base.py b/stain_normalization/callbacks/_base.py new file mode 100644 index 0000000..240b516 --- /dev/null +++ b/stain_normalization/callbacks/_base.py @@ -0,0 +1,32 @@ +from typing import Any + +import numpy as np +import torch +from lightning import Callback +from omegaconf import DictConfig + + +class NormalizationCallback(Callback): + """Base callback providing denormalization helpers for model outputs.""" + + def __init__(self, normalization_config: DictConfig) -> None: + super().__init__() + self.mean = torch.tensor(normalization_config.mean).view(3, 1, 1) + self.std = torch.tensor(normalization_config.std).view(3, 1, 1) + + def denormalize(self, tensor: torch.Tensor) -> torch.Tensor: + """Reverse normalization: tensor → [0, 1] float.""" + device = tensor.device + return (tensor * self.std.to(device)) + self.mean.to(device) + + def tensor_to_image(self, tensor: torch.Tensor) -> np.ndarray[Any, Any]: + """Convert model output tensor to uint8 HWC numpy array.""" + return ( + self.denormalize(tensor) + .clamp(0, 1) + .mul(255) + .byte() + .permute(1, 2, 0) + .cpu() + .numpy() + ) diff --git a/stain_normalization/callbacks/analysis_export.py b/stain_normalization/callbacks/analysis_export.py new file mode 100644 index 0000000..f9ae5ca --- /dev/null +++ b/stain_normalization/callbacks/analysis_export.py @@ -0,0 +1,58 @@ +from pathlib import Path +from typing import Any + +import mlflow +import torch +from lightning import LightningModule, Trainer +from omegaconf import DictConfig + +from stain_normalization.analysis.analyzer import StainAnalyzer +from stain_normalization.callbacks._base import NormalizationCallback + + +class AnalysisExport(NormalizationCallback): + """Exports analysis metrics during testing.""" + + def __init__( + self, output_dir: str | Path, normalization_config: DictConfig + ) -> None: + super().__init__(normalization_config) + self.output_dir = Path(output_dir) + self.output_dir.mkdir(parents=True, exist_ok=True) + + self.mod_analyzer = StainAnalyzer() + self.pred_analyzer = StainAnalyzer() + + def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTPUT + self, + trainer: Trainer, + pl_module: LightningModule, + outputs: list[torch.Tensor], + batch: tuple[torch.Tensor, list[dict[str, Any]]], + batch_idx: int, + dataloader_idx: int = 0, + ) -> None: + """Computes metrics for each sample and accumulates results.""" + for b in range(len(outputs)): + original_img = batch[1][b]["original_image"].astype("uint8") + modified_img = (batch[1][b]["modified_image"] * 255).astype("uint8") + predicted_img = self.tensor_to_image(outputs[b]) + + self.mod_analyzer.compare(modified_img, reference=original_img) + self.pred_analyzer.compare(predicted_img, reference=original_img) + + def on_test_end( + self, + trainer: Trainer, + pl_module: LightningModule, + ) -> None: + """Saves collected metrics as CSV files and logs them as mlflow artifacts.""" + metrics_dir = self.output_dir / "analysis_metrics" + + mod_dir = self.mod_analyzer.save_csv(metrics_dir / "modified") + pred_dir = self.pred_analyzer.save_csv(metrics_dir / "predicted") + + for f in mod_dir.glob("*"): + mlflow.log_artifact(str(f), artifact_path="analysis_metrics/modified") + for f in pred_dir.glob("*"): + mlflow.log_artifact(str(f), artifact_path="analysis_metrics/predicted") diff --git a/stain_normalization/callbacks/tiles_export.py b/stain_normalization/callbacks/tiles_export.py new file mode 100644 index 0000000..79e858c --- /dev/null +++ b/stain_normalization/callbacks/tiles_export.py @@ -0,0 +1,85 @@ +from pathlib import Path +from typing import Any + +import torch +from lightning import LightningModule, Trainer +from omegaconf import DictConfig +from PIL import Image + +from stain_normalization.callbacks._base import NormalizationCallback + + +class TilesExport(NormalizationCallback): + def __init__( + self, + output_dir: str | Path, + normalization_config: DictConfig, + n_first: int = 10, + sample_rate: float = 0.0005, + ) -> None: + super().__init__(normalization_config) + self.output_dir = Path(output_dir) + self.output_dir.mkdir(parents=True, exist_ok=True) + self.n_first = n_first + self.sample_rate = sample_rate + self._tile_count: dict[str, int] = {} + + def tensor_to_image(self, tensor: torch.Tensor) -> Image.Image: # type: ignore[override] # intentional: PIL Image is not subtype of ndarray + return Image.fromarray(super().tensor_to_image(tensor)) + + def _should_save(self, slide_name: str) -> bool: + count = self._tile_count.get(slide_name, 0) + self._tile_count[slide_name] = count + 1 + if count < self.n_first: + return True + return torch.rand(1).item() < self.sample_rate + + def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTPUT + self, + trainer: Trainer, + pl_module: LightningModule, + outputs: list[torch.Tensor], + batch: tuple[torch.Tensor, list[dict[str, Any]]], + batch_idx: int, + dataloader_idx: int = 0, + ) -> None: + _, data = batch + for b in range(len(outputs)): + slide_name = data[b]["slide_name"] + if not self._should_save(slide_name): + continue + + xy = data[b]["xy"] + slide_dir = self.output_dir / slide_name + slide_dir.mkdir(parents=True, exist_ok=True) + + self.tensor_to_image(outputs[b]).save(slide_dir / f"{xy}_predicted.png") + + original_image = Image.fromarray(data[b]["original_image"].astype("uint8")) + original_image.save(slide_dir / f"{xy}_original.png") + + modified_image = Image.fromarray( + (data[b]["modified_image"] * 255).astype("uint8") + ) + modified_image.save(slide_dir / f"{xy}_modified.png") + + def on_predict_batch_end( + self, + trainer: Trainer, + pl_module: LightningModule, + outputs: list[torch.Tensor], + batch: tuple[torch.Tensor, list[dict[str, Any]]], + batch_idx: int, + dataloader_idx: int = 0, + ) -> None: + _, data = batch + for b in range(len(outputs)): + slide_name = data[b]["slide_name"] + if not self._should_save(slide_name): + continue + + xy = data[b]["xy"] + slide_dir = self.output_dir / slide_name + slide_dir.mkdir(parents=True, exist_ok=True) + + self.tensor_to_image(outputs[b]).save(slide_dir / f"{xy}.png") diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py new file mode 100644 index 0000000..b69d6c0 --- /dev/null +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -0,0 +1,217 @@ +import tempfile +import traceback +from dataclasses import dataclass +from pathlib import Path +from typing import Any + +import numpy as np +import torch +from lightning import LightningModule, Trainer +from omegaconf import DictConfig + +from stain_normalization.callbacks._base import NormalizationCallback + + +@dataclass +class _SlideMeta: + path: str + level: int + extent_x: int + extent_y: int + tile_extent_x: int + tile_extent_y: int + mpp_x: float + mpp_y: float + + +@dataclass +class _SlideBuffers: + meta: _SlideMeta + temp_dir: tempfile.TemporaryDirectory[str] + result_buffer: np.memmap[Any, Any] + count_buffer: np.memmap[Any, Any] + + +class WSIAssembler(NormalizationCallback): + """Assembles predicted tiles back into whole-slide pyramid TIFFs.""" + + def __init__( + self, + output_dir: str | Path, + normalization_config: DictConfig, + temp_dir: str | Path | None = None, + ) -> None: + super().__init__(normalization_config) + self.output_dir = Path(output_dir) + self.temp_dir = str(temp_dir) if temp_dir else None + self._slide_meta: dict[str, _SlideMeta] = {} + self._active: _SlideBuffers | None = None + self._active_name: str | None = None + self._failed_slides: list[str] = [] + + def on_predict_start(self, trainer: Trainer, pl_module: LightningModule) -> None: + self.output_dir.mkdir(parents=True, exist_ok=True) + slides_df = trainer.datamodule.predict.slides # type: ignore[attr-defined] # Lightning stub gap + + # Cache metadata only — buffers are opened lazily per slide + for _, row in slides_df.iterrows(): + name = Path(row.path).stem + self._slide_meta[name] = _SlideMeta( + path=row.path, + level=int(row.level), + extent_x=int(row.extent_x), + extent_y=int(row.extent_y), + tile_extent_x=int(row.tile_extent_x), + tile_extent_y=int(row.tile_extent_y), + mpp_x=float(row.mpp_x), + mpp_y=float(row.mpp_y), + ) + + def _open_slide(self, slide_name: str) -> None: + """Allocate memmap buffers for one slide.""" + meta = self._slide_meta[slide_name] + h, w = meta.extent_y, meta.extent_x + + tmp = tempfile.TemporaryDirectory( + prefix=f"wsi_{slide_name}_", dir=self.temp_dir + ) + result_buf = np.memmap( + Path(tmp.name) / "result.raw", + dtype=np.uint8, + mode="w+", + shape=(h, w, 3), + ) + count_buf = np.memmap( + Path(tmp.name) / "count.raw", + dtype=np.uint8, + mode="w+", + shape=(h, w), + ) + + self._active = _SlideBuffers( + meta=meta, + temp_dir=tmp, + result_buffer=result_buf, + count_buffer=count_buf, + ) + self._active_name = slide_name + + def _close_slide(self) -> None: + """Save and free the currently active slide.""" + if self._active is None: + return + assert self._active_name is not None + slide_name = self._active_name + try: + self._save_slide(slide_name, self._active) + except Exception: + print(f"ERROR: Failed to save slide '{slide_name}'") + traceback.print_exc() + self._failed_slides.append(slide_name) + finally: + del self._active.result_buffer + del self._active.count_buffer + self._active.temp_dir.cleanup() + self._active = None + self._active_name = None + + def on_predict_batch_end( + self, + trainer: Trainer, + pl_module: LightningModule, + outputs: list[torch.Tensor], + batch: tuple[torch.Tensor, list[dict[str, Any]]], + batch_idx: int, + dataloader_idx: int = 0, + ) -> None: + for b in range(len(outputs)): + metadata = batch[1][b] + slide_name = metadata["slide_name"] + + if slide_name not in self._slide_meta: + raise ValueError( + f"Slide '{slide_name}' not found in predict dataset metadata. " + f"Available: {list(self._slide_meta.keys())}" + ) + + if slide_name != self._active_name: + self._close_slide() + self._open_slide(slide_name) + + tile = self.tensor_to_image(outputs[b]) + x, y = (int(v) for v in metadata["xy"].split("_")) + self._place_tile(tile, x, y) + + def _place_tile(self, tile: np.ndarray[Any, Any], x: int, y: int) -> None: + """Place a predicted tile into the active slide buffer with overlap averaging.""" + assert self._active is not None + sb = self._active + ex, ey = sb.meta.extent_x, sb.meta.extent_y + + h, w = min(tile.shape[0], ey - y), min(tile.shape[1], ex - x) + tile = tile[:h, :w] + + region = sb.result_buffer[y : y + h, x : x + w] + count = sb.count_buffer[y : y + h, x : x + w] + + # Running average: avg = (old * n + new) / (n + 1) + overlap = count > 0 + if overlap.any(): + n = count[:, :, np.newaxis].astype(np.float32) + blended = np.where( + overlap[:, :, np.newaxis], + (region.astype(np.float32) * n + tile) / (n + 1), + tile, + ) + sb.result_buffer[y : y + h, x : x + w] = np.clip(blended, 0, 255).astype( + np.uint8 + ) + else: + sb.result_buffer[y : y + h, x : x + w] = tile + + sb.count_buffer[y : y + h, x : x + w] = count + 1 + + def on_predict_end(self, trainer: Trainer, pl_module: LightningModule) -> None: + self._close_slide() + if self._failed_slides: + print(f"WARNING: Failed to save {len(self._failed_slides)} slide(s): {self._failed_slides}") + self._slide_meta.clear() + + def _save_slide(self, slide_name: str, sb: _SlideBuffers) -> None: + # Imported here — module-level import causes OpenSlide segfault (libtiff conflict). + import pyvips + + meta = sb.meta + sb.result_buffer.flush() + sb.count_buffer.flush() + + result_path = Path(sb.temp_dir.name) / "result.raw" + count_path = Path(sb.temp_dir.name) / "count.raw" + + result_img = pyvips.Image.rawload( + str(result_path), meta.extent_x, meta.extent_y, 3 + ) + result_img = result_img.copy(interpretation=pyvips.Interpretation.SRGB) + + count_img = pyvips.Image.rawload( + str(count_path), meta.extent_x, meta.extent_y, 1 + ) + mask = count_img > 0 + # add white background for untouched areas (count=0) + white = (pyvips.Image.black(meta.extent_x, meta.extent_y, bands=3) + 255).cast( + pyvips.BandFormat.UCHAR + ) + final_img = mask.ifthenelse(result_img, white) + + output_path = self.output_dir / f"{slide_name}_norm.tiff" + final_img.tiffsave( + str(output_path), + bigtiff=True, + compression=pyvips.enums.ForeignTiffCompression.DEFLATE, + tile=True, + tile_width=512, + tile_height=512, + pyramid=True, + xres=1000.0 / meta.mpp_x, + yres=1000.0 / meta.mpp_y, + ) diff --git a/stain_normalization/metrics/__init__.py b/stain_normalization/metrics/__init__.py new file mode 100644 index 0000000..8153500 --- /dev/null +++ b/stain_normalization/metrics/__init__.py @@ -0,0 +1,16 @@ +from stain_normalization.metrics.image_metrics import ( + compute_lab_brightness_psnr, + compute_nmi, + compute_pcc, +) +from stain_normalization.metrics.vector_metrics import ( + compare_vectors, +) + + +__all__ = [ + "compare_vectors", + "compute_lab_brightness_psnr", + "compute_nmi", + "compute_pcc", +] diff --git a/stain_normalization/metrics/image_metrics.py b/stain_normalization/metrics/image_metrics.py new file mode 100644 index 0000000..daad52e --- /dev/null +++ b/stain_normalization/metrics/image_metrics.py @@ -0,0 +1,62 @@ +from typing import Any + +import numpy as np +from skimage.color import rgb2lab +from skimage.metrics import peak_signal_noise_ratio + + +def compute_nmi(img: np.ndarray[Any, Any]) -> float: + """Normalized Median Intensity — measures relative brightness of an image. + + Args: + img: RGB image. + + Returns: + Ratio of median to 95th percentile intensity. + """ + avg_rgb = img.mean(axis=2) + median_val = np.median(avg_rgb) + p95_val = np.percentile(avg_rgb, 95) + + if p95_val == 0: + return 0.0 + + return float(median_val / p95_val) + + +def compute_pcc(img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any]) -> float: + """Pearson Correlation Coefficient between two images. + + Args: + img1: First image. + img2: Second image. + + Returns: + PCC value, or 0.0 if either image has zero variance. + """ + img1_flat = img1.flatten().astype(np.float64) + img2_flat = img2.flatten().astype(np.float64) + + if np.std(img1_flat) == 0 or np.std(img2_flat) == 0: + return 0.0 + + return float(np.corrcoef(img1_flat, img2_flat)[0, 1]) + + +def compute_lab_brightness_psnr( + img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any] +) -> float: + """PSNR on the L* channel in Lab color space. + + Args: + img1: First RGB image. + img2: Second RGB image. + + Returns: + PSNR in dB on the lightness channel. + """ + lab1 = rgb2lab(img1.astype(np.float32) / 255.0) + lab2 = rgb2lab(img2.astype(np.float32) / 255.0) + return float( + peak_signal_noise_ratio(lab1[:, :, 0], lab2[:, :, 0], data_range=100.0) + ) diff --git a/stain_normalization/metrics/vector_metrics.py b/stain_normalization/metrics/vector_metrics.py new file mode 100644 index 0000000..1e791dd --- /dev/null +++ b/stain_normalization/metrics/vector_metrics.py @@ -0,0 +1,75 @@ +from typing import Any + +import numpy as np +from skimage.color import rgb2lab + + +def _od_to_lab(od_vector: np.ndarray[Any, Any]) -> np.ndarray[Any, Any]: + """Convert optical density vector to Lab color. + + Args: + od_vector: Stain vector in optical density space. + + Returns: + Color in Lab space as [L, a, b]. + """ + # Calculate RGB from optical density by reversing the process in estimate_stain_vectors. + # default i0=240 (transmitted light intensity) + rgb = np.clip(240 * np.exp(-od_vector), 0, 255) / 255.0 + return rgb2lab(rgb.reshape(1, 1, 3)).flatten() + + +def delta_e76(lab1: np.ndarray[Any, Any], lab2: np.ndarray[Any, Any]) -> float: + """CIE76 Delta E with dL=0 (chromaticity only). + + CIE76 Delta E is sqrt(dL^2 + da^2 + db^2). We set dL=0 because we compare + dyes not colors, so brightness is irrelevant. + + Args: + lab1: First color in Lab space. + lab2: Second color in Lab space. + + Returns: + sqrt(da^2 + db^2). + """ + da = lab1[1] - lab2[1] + db = lab1[2] - lab2[2] + return float(np.sqrt(da**2 + db**2)) + + +def compare_vectors( + vecs1: np.ndarray[Any, Any], + vecs2: np.ndarray[Any, Any], +) -> dict[str, float | bool]: + """Compare two sets of stain vectors in Lab chromaticity space. + + Args: + vecs1: Stain vectors from the first image in OD space. + vecs2: Stain vectors from the second image in OD space. + + Returns: + Dict with d_hematoxylin, d_eosin and was_swapped. + Returns NaN distances if either vector set contains NaN. + """ + if np.any(np.isnan(vecs1)) or np.any(np.isnan(vecs2)): + return { + "d_hematoxylin": float("nan"), + "d_eosin": float("nan"), + "was_swapped": False, + } + + sim_straight = np.dot(vecs1[0], vecs2[0]) + np.dot(vecs1[1], vecs2[1]) + sim_swapped = np.dot(vecs1[0], vecs2[1]) + np.dot(vecs1[1], vecs2[0]) + was_swapped = sim_swapped > sim_straight + vecs2_paired = vecs2[[1, 0]] if was_swapped else vecs2 + + lab1_a = _od_to_lab(vecs1[0]) + lab1_b = _od_to_lab(vecs1[1]) + lab2_a = _od_to_lab(vecs2_paired[0]) + lab2_b = _od_to_lab(vecs2_paired[1]) + + return { + "d_hematoxylin": delta_e76(lab1_a, lab2_a), + "d_eosin": delta_e76(lab1_b, lab2_b), + "was_swapped": was_swapped, + } From cce02641ae08cdd585210fb5ec59ee1a9c79ced1 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Tue, 17 Mar 2026 14:13:00 +0100 Subject: [PATCH 02/13] chore: fix lint --- stain_normalization/callbacks/wsi_assembler.py | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py index b69d6c0..3b7e639 100644 --- a/stain_normalization/callbacks/wsi_assembler.py +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -174,7 +174,9 @@ def _place_tile(self, tile: np.ndarray[Any, Any], x: int, y: int) -> None: def on_predict_end(self, trainer: Trainer, pl_module: LightningModule) -> None: self._close_slide() if self._failed_slides: - print(f"WARNING: Failed to save {len(self._failed_slides)} slide(s): {self._failed_slides}") + print( + f"WARNING: Failed to save {len(self._failed_slides)} slide(s): {self._failed_slides}" + ) self._slide_meta.clear() def _save_slide(self, slide_name: str, sb: _SlideBuffers) -> None: From 8aed482961df81fb53abb0888aff1f725496517b Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Tue, 17 Mar 2026 15:09:14 +0100 Subject: [PATCH 03/13] feat: add mean brightness metric --- stain_normalization/analysis/analyzer.py | 24 +++++++++++++++++--- stain_normalization/metrics/image_metrics.py | 13 +++++++++++ 2 files changed, 34 insertions(+), 3 deletions(-) diff --git a/stain_normalization/analysis/analyzer.py b/stain_normalization/analysis/analyzer.py index 05f2a8f..c5e9276 100644 --- a/stain_normalization/analysis/analyzer.py +++ b/stain_normalization/analysis/analyzer.py @@ -14,6 +14,7 @@ from stain_normalization.metrics.image_metrics import ( compute_lab_brightness_psnr, + compute_mean_brightness, compute_nmi, compute_pcc, ) @@ -24,8 +25,8 @@ class StainAnalyzer: """Compare images using selected metrics, accumulate results. Args: - reference: Optional fixed reference image. If given, stain vectors - and NMI are pre-computed once. + reference: Optional fixed reference image. If given, stain vectors, + NMI, and mean brightness are pre-computed once. metrics: Which metrics to compute. None = all. """ @@ -35,6 +36,7 @@ class StainAnalyzer: "pcc", "nmi", "lab_psnr", + "mean_brightness", ] PAIRED_ONLY: ClassVar[set[str]] = {"ssim", "pcc", "lab_psnr"} @@ -52,16 +54,19 @@ def __init__( f"Unknown metric '{m}'. Available: {self.AVAILABLE_METRICS}" ) - # if we have reference image, precompute stain vectors and NMI + # if we have reference image, precompute stain vectors, NMI, and brightness self._ref_img = reference self._ref_vectors = None self._ref_nmi = None + self._ref_brightness = None if reference is not None: if "vectors" in self.metrics: self._ref_vectors = estimate_stain_vectors(reference) if "nmi" in self.metrics: self._ref_nmi = compute_nmi(reference) + if "mean_brightness" in self.metrics: + self._ref_brightness = compute_mean_brightness(reference) @property def results(self) -> pd.DataFrame: @@ -101,9 +106,15 @@ def compare( estimate_stain_vectors(ref_img) if "vectors" in self.metrics else None ) ref_nmi = compute_nmi(ref_img) if "nmi" in self.metrics else None + ref_brightness = ( + compute_mean_brightness(ref_img) + if "mean_brightness" in self.metrics + else None + ) else: ref_vectors = self._ref_vectors ref_nmi = self._ref_nmi + ref_brightness = self._ref_brightness result: dict[str, Any] = {"id": image_id} if image_id is not None else {} @@ -145,6 +156,13 @@ def compare( if "lab_psnr" in self.metrics and is_paired: result["lab_brightness_psnr"] = compute_lab_brightness_psnr(ref_img, image) + if "mean_brightness" in self.metrics: + assert ref_brightness is not None + img_brightness = compute_mean_brightness(image) + result["ref_mean_brightness"] = ref_brightness + result["mean_brightness"] = img_brightness + result["mean_brightness_diff"] = img_brightness - ref_brightness + self._results.append(result) return result diff --git a/stain_normalization/metrics/image_metrics.py b/stain_normalization/metrics/image_metrics.py index daad52e..8b7aaf5 100644 --- a/stain_normalization/metrics/image_metrics.py +++ b/stain_normalization/metrics/image_metrics.py @@ -43,6 +43,19 @@ def compute_pcc(img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any]) -> float return float(np.corrcoef(img1_flat, img2_flat)[0, 1]) +def compute_mean_brightness(img: np.ndarray[Any, Any]) -> float: + """Mean L* brightness of an image in CIE Lab color space. + + Args: + img: RGB image (uint8). + + Returns: + Mean L* value (0–100 scale, higher = brighter). + """ + lab = rgb2lab(img) + return float(lab[:, :, 0].mean()) + + def compute_lab_brightness_psnr( img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any] ) -> float: From e50c10689d0541192bebff5dc12ee48bc6507361 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Tue, 17 Mar 2026 15:44:09 +0100 Subject: [PATCH 04/13] fix: review ai agent feedback --- configs/default.yaml | 1 + stain_normalization/analysis/analyzer.py | 21 +++++++++++-------- .../callbacks/analysis_export.py | 7 ++++--- stain_normalization/callbacks/tiles_export.py | 5 +++-- .../callbacks/wsi_assembler.py | 8 +++++-- stain_normalization/metrics/image_metrics.py | 4 ++-- 6 files changed, 28 insertions(+), 18 deletions(-) diff --git a/configs/default.yaml b/configs/default.yaml index f2f8c4b..5944109 100644 --- a/configs/default.yaml +++ b/configs/default.yaml @@ -20,6 +20,7 @@ callbacks: monitor: validation/loss mode: min + # opt-in callbacks — add to trainer.callbacks when needed tiles_export: _target_: stain_normalization.callbacks.TilesExport output_dir: ${output_dir} diff --git a/stain_normalization/analysis/analyzer.py b/stain_normalization/analysis/analyzer.py index c5e9276..ea63306 100644 --- a/stain_normalization/analysis/analyzer.py +++ b/stain_normalization/analysis/analyzer.py @@ -63,6 +63,10 @@ def __init__( if reference is not None: if "vectors" in self.metrics: self._ref_vectors = estimate_stain_vectors(reference) + if np.isnan(self._ref_vectors).any(): + raise ValueError( + "Reference image has too much background; no valid stain vectors found." + ) if "nmi" in self.metrics: self._ref_nmi = compute_nmi(reference) if "mean_brightness" in self.metrics: @@ -81,27 +85,28 @@ def compare( self, image: np.ndarray[Any, Any], image_id: str | None = None, - reference: np.ndarray[Any, Any] | None = None, + paired_image: np.ndarray[Any, Any] | None = None, ) -> dict[str, Any]: """Compare an image against the reference and store the result. Args: image: Image to compare. image_id: Optional identifier for this comparison. - reference: Override reference image for this call. + paired_image: Paired original image for this specific tile. + When provided, structural metrics (SSIM, PCC, Lab PSNR) are computed. Returns: Dict with metric results. """ - ref_img = reference if reference is not None else self._ref_img + ref_img = paired_image if paired_image is not None else self._ref_img if ref_img is None: raise ValueError( "No reference image. Pass one to __init__ or to compare()." ) - is_paired = reference is not None + is_paired = paired_image is not None - if reference is not None: + if paired_image is not None: ref_vectors = ( estimate_stain_vectors(ref_img) if "vectors" in self.metrics else None ) @@ -118,10 +123,8 @@ def compare( result: dict[str, Any] = {"id": image_id} if image_id is not None else {} - if "vectors" in self.metrics: - assert ( - ref_vectors is not None - ) # fails if reference has too much background and no valid stain vectors + if "vectors" in self.metrics and ref_vectors is not None: + # ref_vectors can be None for paired tiles with too much background img_vectors = estimate_stain_vectors(image) vec_result = compare_vectors(ref_vectors, img_vectors) result.update(vec_result) diff --git a/stain_normalization/callbacks/analysis_export.py b/stain_normalization/callbacks/analysis_export.py index f9ae5ca..117b8d1 100644 --- a/stain_normalization/callbacks/analysis_export.py +++ b/stain_normalization/callbacks/analysis_export.py @@ -8,6 +8,7 @@ from stain_normalization.analysis.analyzer import StainAnalyzer from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.type_aliases import Outputs class AnalysisExport(NormalizationCallback): @@ -27,7 +28,7 @@ def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTP self, trainer: Trainer, pl_module: LightningModule, - outputs: list[torch.Tensor], + outputs: Outputs, batch: tuple[torch.Tensor, list[dict[str, Any]]], batch_idx: int, dataloader_idx: int = 0, @@ -38,8 +39,8 @@ def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTP modified_img = (batch[1][b]["modified_image"] * 255).astype("uint8") predicted_img = self.tensor_to_image(outputs[b]) - self.mod_analyzer.compare(modified_img, reference=original_img) - self.pred_analyzer.compare(predicted_img, reference=original_img) + self.mod_analyzer.compare(modified_img, paired_image=original_img) + self.pred_analyzer.compare(predicted_img, paired_image=original_img) def on_test_end( self, diff --git a/stain_normalization/callbacks/tiles_export.py b/stain_normalization/callbacks/tiles_export.py index 79e858c..8e1862a 100644 --- a/stain_normalization/callbacks/tiles_export.py +++ b/stain_normalization/callbacks/tiles_export.py @@ -7,6 +7,7 @@ from PIL import Image from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.type_aliases import Outputs class TilesExport(NormalizationCallback): @@ -38,7 +39,7 @@ def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTP self, trainer: Trainer, pl_module: LightningModule, - outputs: list[torch.Tensor], + outputs: Outputs, batch: tuple[torch.Tensor, list[dict[str, Any]]], batch_idx: int, dataloader_idx: int = 0, @@ -67,7 +68,7 @@ def on_predict_batch_end( self, trainer: Trainer, pl_module: LightningModule, - outputs: list[torch.Tensor], + outputs: Outputs, batch: tuple[torch.Tensor, list[dict[str, Any]]], batch_idx: int, dataloader_idx: int = 0, diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py index 3b7e639..7698b7e 100644 --- a/stain_normalization/callbacks/wsi_assembler.py +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -10,6 +10,7 @@ from omegaconf import DictConfig from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.type_aliases import Outputs @dataclass @@ -119,7 +120,7 @@ def on_predict_batch_end( self, trainer: Trainer, pl_module: LightningModule, - outputs: list[torch.Tensor], + outputs: Outputs, batch: tuple[torch.Tensor, list[dict[str, Any]]], batch_idx: int, dataloader_idx: int = 0, @@ -148,7 +149,10 @@ def _place_tile(self, tile: np.ndarray[Any, Any], x: int, y: int) -> None: sb = self._active ex, ey = sb.meta.extent_x, sb.meta.extent_y - h, w = min(tile.shape[0], ey - y), min(tile.shape[1], ex - x) + h = max(0, min(tile.shape[0], ey - y)) + w = max(0, min(tile.shape[1], ex - x)) + if h == 0 or w == 0: + return tile = tile[:h, :w] region = sb.result_buffer[y : y + h, x : x + w] diff --git a/stain_normalization/metrics/image_metrics.py b/stain_normalization/metrics/image_metrics.py index 8b7aaf5..36463f7 100644 --- a/stain_normalization/metrics/image_metrics.py +++ b/stain_normalization/metrics/image_metrics.py @@ -68,8 +68,8 @@ def compute_lab_brightness_psnr( Returns: PSNR in dB on the lightness channel. """ - lab1 = rgb2lab(img1.astype(np.float32) / 255.0) - lab2 = rgb2lab(img2.astype(np.float32) / 255.0) + lab1 = rgb2lab(img1) + lab2 = rgb2lab(img2) return float( peak_signal_noise_ratio(lab1[:, :, 0], lab2[:, :, 0], data_range=100.0) ) From 0052904554d0c6f302d53b5519104f62dcc24572 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Tue, 17 Mar 2026 17:15:35 +0100 Subject: [PATCH 05/13] fix: review ai agent feedback --- stain_normalization/analysis/analyzer.py | 4 +++- stain_normalization/metrics/image_metrics.py | 2 +- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/stain_normalization/analysis/analyzer.py b/stain_normalization/analysis/analyzer.py index ea63306..1118013 100644 --- a/stain_normalization/analysis/analyzer.py +++ b/stain_normalization/analysis/analyzer.py @@ -27,7 +27,7 @@ class StainAnalyzer: Args: reference: Optional fixed reference image. If given, stain vectors, NMI, and mean brightness are pre-computed once. - metrics: Which metrics to compute. None = all. + metrics: Which metrics to compute. None or [] = all. """ AVAILABLE_METRICS: ClassVar[list[str]] = [ @@ -179,6 +179,8 @@ def get_statistics(self) -> pd.DataFrame: """ df = self.results numeric_cols = df.select_dtypes(include=[np.number]).columns + if df.empty or len(numeric_cols) == 0: + return pd.DataFrame() return df[numeric_cols].describe(percentiles=[0.05, 0.25, 0.5, 0.75, 0.95]) def get_baseline_ranges( diff --git a/stain_normalization/metrics/image_metrics.py b/stain_normalization/metrics/image_metrics.py index 36463f7..f430772 100644 --- a/stain_normalization/metrics/image_metrics.py +++ b/stain_normalization/metrics/image_metrics.py @@ -50,7 +50,7 @@ def compute_mean_brightness(img: np.ndarray[Any, Any]) -> float: img: RGB image (uint8). Returns: - Mean L* value (0–100 scale, higher = brighter). + Mean L* value (0-100 scale, higher = brighter). """ lab = rgb2lab(img) return float(lab[:, :, 0].mean()) From 8989a9107859cdec2f23ded8ed16554d8eeeb53b Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Wed, 18 Mar 2026 14:53:59 +0100 Subject: [PATCH 06/13] fix: review feedback --- stain_normalization/callbacks/__init__.py | 4 ++-- stain_normalization/callbacks/_base.py | 2 +- stain_normalization/callbacks/analysis_export.py | 4 ++-- stain_normalization/callbacks/tiles_export.py | 4 ++-- stain_normalization/callbacks/wsi_assembler.py | 4 ++-- stain_normalization/metrics/image_metrics.py | 11 +++++------ stain_normalization/metrics/vector_metrics.py | 11 +++++------ 7 files changed, 19 insertions(+), 21 deletions(-) diff --git a/stain_normalization/callbacks/__init__.py b/stain_normalization/callbacks/__init__.py index 4aeaf95..09f4235 100644 --- a/stain_normalization/callbacks/__init__.py +++ b/stain_normalization/callbacks/__init__.py @@ -1,7 +1,7 @@ -from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.callbacks._base import DenormalizationCallback from stain_normalization.callbacks.analysis_export import AnalysisExport from stain_normalization.callbacks.tiles_export import TilesExport from stain_normalization.callbacks.wsi_assembler import WSIAssembler -__all__ = ["AnalysisExport", "NormalizationCallback", "TilesExport", "WSIAssembler"] +__all__ = ["AnalysisExport", "DenormalizationCallback", "TilesExport", "WSIAssembler"] diff --git a/stain_normalization/callbacks/_base.py b/stain_normalization/callbacks/_base.py index 240b516..ce24a6e 100644 --- a/stain_normalization/callbacks/_base.py +++ b/stain_normalization/callbacks/_base.py @@ -6,7 +6,7 @@ from omegaconf import DictConfig -class NormalizationCallback(Callback): +class DenormalizationCallback(Callback): """Base callback providing denormalization helpers for model outputs.""" def __init__(self, normalization_config: DictConfig) -> None: diff --git a/stain_normalization/callbacks/analysis_export.py b/stain_normalization/callbacks/analysis_export.py index 117b8d1..52ccc46 100644 --- a/stain_normalization/callbacks/analysis_export.py +++ b/stain_normalization/callbacks/analysis_export.py @@ -7,11 +7,11 @@ from omegaconf import DictConfig from stain_normalization.analysis.analyzer import StainAnalyzer -from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.callbacks._base import DenormalizationCallback from stain_normalization.type_aliases import Outputs -class AnalysisExport(NormalizationCallback): +class AnalysisExport(DenormalizationCallback): """Exports analysis metrics during testing.""" def __init__( diff --git a/stain_normalization/callbacks/tiles_export.py b/stain_normalization/callbacks/tiles_export.py index 8e1862a..d1bb6cd 100644 --- a/stain_normalization/callbacks/tiles_export.py +++ b/stain_normalization/callbacks/tiles_export.py @@ -6,11 +6,11 @@ from omegaconf import DictConfig from PIL import Image -from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.callbacks._base import DenormalizationCallback from stain_normalization.type_aliases import Outputs -class TilesExport(NormalizationCallback): +class TilesExport(DenormalizationCallback): def __init__( self, output_dir: str | Path, diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py index 7698b7e..db6dbea 100644 --- a/stain_normalization/callbacks/wsi_assembler.py +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -9,7 +9,7 @@ from lightning import LightningModule, Trainer from omegaconf import DictConfig -from stain_normalization.callbacks._base import NormalizationCallback +from stain_normalization.callbacks._base import DenormalizationCallback from stain_normalization.type_aliases import Outputs @@ -33,7 +33,7 @@ class _SlideBuffers: count_buffer: np.memmap[Any, Any] -class WSIAssembler(NormalizationCallback): +class WSIAssembler(DenormalizationCallback): """Assembles predicted tiles back into whole-slide pyramid TIFFs.""" def __init__( diff --git a/stain_normalization/metrics/image_metrics.py b/stain_normalization/metrics/image_metrics.py index f430772..ac84db1 100644 --- a/stain_normalization/metrics/image_metrics.py +++ b/stain_normalization/metrics/image_metrics.py @@ -1,11 +1,10 @@ -from typing import Any - import numpy as np +from numpy.typing import NDArray from skimage.color import rgb2lab from skimage.metrics import peak_signal_noise_ratio -def compute_nmi(img: np.ndarray[Any, Any]) -> float: +def compute_nmi(img: NDArray[np.uint8]) -> float: """Normalized Median Intensity — measures relative brightness of an image. Args: @@ -24,7 +23,7 @@ def compute_nmi(img: np.ndarray[Any, Any]) -> float: return float(median_val / p95_val) -def compute_pcc(img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any]) -> float: +def compute_pcc(img1: NDArray[np.uint8], img2: NDArray[np.uint8]) -> float: """Pearson Correlation Coefficient between two images. Args: @@ -43,7 +42,7 @@ def compute_pcc(img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any]) -> float return float(np.corrcoef(img1_flat, img2_flat)[0, 1]) -def compute_mean_brightness(img: np.ndarray[Any, Any]) -> float: +def compute_mean_brightness(img: NDArray[np.uint8]) -> float: """Mean L* brightness of an image in CIE Lab color space. Args: @@ -57,7 +56,7 @@ def compute_mean_brightness(img: np.ndarray[Any, Any]) -> float: def compute_lab_brightness_psnr( - img1: np.ndarray[Any, Any], img2: np.ndarray[Any, Any] + img1: NDArray[np.uint8], img2: NDArray[np.uint8] ) -> float: """PSNR on the L* channel in Lab color space. diff --git a/stain_normalization/metrics/vector_metrics.py b/stain_normalization/metrics/vector_metrics.py index 1e791dd..b7b79d1 100644 --- a/stain_normalization/metrics/vector_metrics.py +++ b/stain_normalization/metrics/vector_metrics.py @@ -1,10 +1,9 @@ -from typing import Any - import numpy as np +from numpy.typing import NDArray from skimage.color import rgb2lab -def _od_to_lab(od_vector: np.ndarray[Any, Any]) -> np.ndarray[Any, Any]: +def _od_to_lab(od_vector: NDArray[np.floating]) -> NDArray[np.floating]: """Convert optical density vector to Lab color. Args: @@ -19,7 +18,7 @@ def _od_to_lab(od_vector: np.ndarray[Any, Any]) -> np.ndarray[Any, Any]: return rgb2lab(rgb.reshape(1, 1, 3)).flatten() -def delta_e76(lab1: np.ndarray[Any, Any], lab2: np.ndarray[Any, Any]) -> float: +def delta_e76(lab1: NDArray[np.floating], lab2: NDArray[np.floating]) -> float: """CIE76 Delta E with dL=0 (chromaticity only). CIE76 Delta E is sqrt(dL^2 + da^2 + db^2). We set dL=0 because we compare @@ -38,8 +37,8 @@ def delta_e76(lab1: np.ndarray[Any, Any], lab2: np.ndarray[Any, Any]) -> float: def compare_vectors( - vecs1: np.ndarray[Any, Any], - vecs2: np.ndarray[Any, Any], + vecs1: NDArray[np.floating], + vecs2: NDArray[np.floating], ) -> dict[str, float | bool]: """Compare two sets of stain vectors in Lab chromaticity space. From e964f1f70c7b215ef3127183f90e00fbac817245 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Thu, 19 Mar 2026 01:05:09 +0100 Subject: [PATCH 07/13] feat: use multi-dataloader --- stain_normalization/callbacks/tiles_export.py | 12 ++-- .../callbacks/wsi_assembler.py | 72 +++++++++---------- stain_normalization/data/data_module.py | 34 +++++---- .../data/datasets/predict_dataset.py | 4 +- .../data/datasets/test_dataset.py | 4 +- .../stain_normalization_model.py | 4 +- 6 files changed, 67 insertions(+), 63 deletions(-) diff --git a/stain_normalization/callbacks/tiles_export.py b/stain_normalization/callbacks/tiles_export.py index d1bb6cd..8e3dfee 100644 --- a/stain_normalization/callbacks/tiles_export.py +++ b/stain_normalization/callbacks/tiles_export.py @@ -23,14 +23,14 @@ def __init__( self.output_dir.mkdir(parents=True, exist_ok=True) self.n_first = n_first self.sample_rate = sample_rate - self._tile_count: dict[str, int] = {} + self._global_count: int = 0 def tensor_to_image(self, tensor: torch.Tensor) -> Image.Image: # type: ignore[override] # intentional: PIL Image is not subtype of ndarray return Image.fromarray(super().tensor_to_image(tensor)) - def _should_save(self, slide_name: str) -> bool: - count = self._tile_count.get(slide_name, 0) - self._tile_count[slide_name] = count + 1 + def _should_save(self) -> bool: + count = self._global_count + self._global_count += 1 if count < self.n_first: return True return torch.rand(1).item() < self.sample_rate @@ -47,7 +47,7 @@ def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTP _, data = batch for b in range(len(outputs)): slide_name = data[b]["slide_name"] - if not self._should_save(slide_name): + if not self._should_save(): continue xy = data[b]["xy"] @@ -76,7 +76,7 @@ def on_predict_batch_end( _, data = batch for b in range(len(outputs)): slide_name = data[b]["slide_name"] - if not self._should_save(slide_name): + if not self._should_save(): continue xy = data[b]["xy"] diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py index db6dbea..fbf6d7f 100644 --- a/stain_normalization/callbacks/wsi_assembler.py +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -8,6 +8,7 @@ import torch from lightning import LightningModule, Trainer from omegaconf import DictConfig +from rationai.mlkit.lightning.callbacks import MultiloaderLifecycle from stain_normalization.callbacks._base import DenormalizationCallback from stain_normalization.type_aliases import Outputs @@ -33,8 +34,12 @@ class _SlideBuffers: count_buffer: np.memmap[Any, Any] -class WSIAssembler(DenormalizationCallback): - """Assembles predicted tiles back into whole-slide pyramid TIFFs.""" +class WSIAssembler(DenormalizationCallback, MultiloaderLifecycle): + """Assembles predicted tiles back into whole-slide pyramid TIFFs. + + Uses one dataloader per slide (via MultiloaderLifecycle) — buffers are + opened on dataloader start and saved/freed on dataloader end. + """ def __init__( self, @@ -42,35 +47,41 @@ def __init__( normalization_config: DictConfig, temp_dir: str | Path | None = None, ) -> None: - super().__init__(normalization_config) + DenormalizationCallback.__init__(self, normalization_config) + MultiloaderLifecycle.__init__(self) self.output_dir = Path(output_dir) self.temp_dir = str(temp_dir) if temp_dir else None - self._slide_meta: dict[str, _SlideMeta] = {} self._active: _SlideBuffers | None = None self._active_name: str | None = None self._failed_slides: list[str] = [] def on_predict_start(self, trainer: Trainer, pl_module: LightningModule) -> None: self.output_dir.mkdir(parents=True, exist_ok=True) - slides_df = trainer.datamodule.predict.slides # type: ignore[attr-defined] # Lightning stub gap - - # Cache metadata only — buffers are opened lazily per slide - for _, row in slides_df.iterrows(): - name = Path(row.path).stem - self._slide_meta[name] = _SlideMeta( - path=row.path, - level=int(row.level), - extent_x=int(row.extent_x), - extent_y=int(row.extent_y), - tile_extent_x=int(row.tile_extent_x), - tile_extent_y=int(row.tile_extent_y), - mpp_x=float(row.mpp_x), - mpp_y=float(row.mpp_y), - ) - def _open_slide(self, slide_name: str) -> None: + def on_predict_dataloader_start( + self, trainer: Trainer, pl_module: LightningModule, dataloader_idx: int + ) -> None: + slide = trainer.datamodule.predict.slides[dataloader_idx] # type: ignore[attr-defined] + meta = _SlideMeta( + path=slide["path"], + level=int(slide["level"]), + extent_x=int(slide["extent_x"]), + extent_y=int(slide["extent_y"]), + tile_extent_x=int(slide["tile_extent_x"]), + tile_extent_y=int(slide["tile_extent_y"]), + mpp_x=float(slide["mpp_x"]), + mpp_y=float(slide["mpp_y"]), + ) + slide_name = Path(slide["path"]).stem + self._open_slide(slide_name, meta) + + def on_predict_dataloader_end( + self, trainer: Trainer, pl_module: LightningModule, dataloader_idx: int + ) -> None: + self._close_slide() + + def _open_slide(self, slide_name: str, meta: _SlideMeta) -> None: """Allocate memmap buffers for one slide.""" - meta = self._slide_meta[slide_name] h, w = meta.extent_y, meta.extent_x tmp = tempfile.TemporaryDirectory( @@ -126,20 +137,8 @@ def on_predict_batch_end( dataloader_idx: int = 0, ) -> None: for b in range(len(outputs)): - metadata = batch[1][b] - slide_name = metadata["slide_name"] - - if slide_name not in self._slide_meta: - raise ValueError( - f"Slide '{slide_name}' not found in predict dataset metadata. " - f"Available: {list(self._slide_meta.keys())}" - ) - - if slide_name != self._active_name: - self._close_slide() - self._open_slide(slide_name) - tile = self.tensor_to_image(outputs[b]) + metadata = batch[1][b] x, y = (int(v) for v in metadata["xy"].split("_")) self._place_tile(tile, x, y) @@ -176,12 +175,11 @@ def _place_tile(self, tile: np.ndarray[Any, Any], x: int, y: int) -> None: sb.count_buffer[y : y + h, x : x + w] = count + 1 def on_predict_end(self, trainer: Trainer, pl_module: LightningModule) -> None: - self._close_slide() if self._failed_slides: print( - f"WARNING: Failed to save {len(self._failed_slides)} slide(s): {self._failed_slides}" + f"WARNING: Failed to save {len(self._failed_slides)} slide(s): " + f"{self._failed_slides}" ) - self._slide_meta.clear() def _save_slide(self, slide_name: str, sb: _SlideBuffers) -> None: # Imported here — module-level import causes OpenSlide segfault (libtiff conflict). diff --git a/stain_normalization/data/data_module.py b/stain_normalization/data/data_module.py index a3c42f1..2ab8f3d 100644 --- a/stain_normalization/data/data_module.py +++ b/stain_normalization/data/data_module.py @@ -54,18 +54,24 @@ def val_dataloader(self) -> Iterable[Batch]: persistent_workers=self.num_workers > 0, ) - def test_dataloader(self) -> Iterable[PredictBatch]: - return DataLoader( - self.test, - batch_size=self.batch_size, - num_workers=self.num_workers, - collate_fn=collate_fn, - ) + def test_dataloader(self) -> list[DataLoader[PredictBatch]]: + return [ + DataLoader( + dataset, + batch_size=self.batch_size, + num_workers=self.num_workers, + collate_fn=collate_fn, + ) + for dataset in self.test.datasets + ] - def predict_dataloader(self) -> Iterable[PredictBatch]: - return DataLoader( - self.predict, - batch_size=self.batch_size, - num_workers=self.num_workers, - collate_fn=collate_fn, - ) + def predict_dataloader(self) -> list[DataLoader[PredictBatch]]: + return [ + DataLoader( + dataset, + batch_size=self.batch_size, + num_workers=self.num_workers, + collate_fn=collate_fn, + ) + for dataset in self.predict.datasets + ] diff --git a/stain_normalization/data/datasets/predict_dataset.py b/stain_normalization/data/datasets/predict_dataset.py index 25ec978..a35ad86 100644 --- a/stain_normalization/data/datasets/predict_dataset.py +++ b/stain_normalization/data/datasets/predict_dataset.py @@ -64,8 +64,8 @@ def __len__(self) -> int: def __getitem__(self, idx: int) -> PredictSample: input_image_255 = self.slide_tiles[idx] slide_name = self.slide_tiles.slide_path.stem - x = self.slide_tiles.tiles.iloc[idx]["x"] - y = self.slide_tiles.tiles.iloc[idx]["y"] + tile = self.slide_tiles.tiles[idx] + x, y = tile["x"], tile["y"] input_image = input_image_255 / 255.0 diff --git a/stain_normalization/data/datasets/test_dataset.py b/stain_normalization/data/datasets/test_dataset.py index 26a7ffb..f636c04 100644 --- a/stain_normalization/data/datasets/test_dataset.py +++ b/stain_normalization/data/datasets/test_dataset.py @@ -70,8 +70,8 @@ def __len__(self) -> int: def __getitem__(self, idx: int) -> PredictSample: original_image_255 = self.slide_tiles[idx] slide_name = self.slide_tiles.slide_path.stem - x = self.slide_tiles.tiles.iloc[idx]["x"] - y = self.slide_tiles.tiles.iloc[idx]["y"] + tile = self.slide_tiles.tiles[idx] + x, y = tile["x"], tile["y"] # Create "wrong" image to use as input. Outputs image in float 0-1 modified_image_raw = self.modify(image=original_image_255)["image"] diff --git a/stain_normalization/stain_normalization_model.py b/stain_normalization/stain_normalization_model.py index 7b03e86..1591be4 100644 --- a/stain_normalization/stain_normalization_model.py +++ b/stain_normalization/stain_normalization_model.py @@ -60,7 +60,7 @@ def validation_step(self, batch: Batch) -> None: on_epoch=True, ) - def test_step(self, batch: PredictBatch) -> Outputs: + def test_step(self, batch: PredictBatch, batch_idx: int = 0, dataloader_idx: int = 0) -> Outputs: inputs, data = batch outputs = self(inputs) targets = stack([item["original_image_tensor"] for item in data]).to( @@ -74,7 +74,7 @@ def test_step(self, batch: PredictBatch) -> Outputs: ) return outputs - def predict_step(self, batch: PredictBatch, batch_idx: int) -> Outputs: + def predict_step(self, batch: PredictBatch, batch_idx: int = 0, dataloader_idx: int = 0) -> Outputs: inputs = batch[0] return self(inputs) From 0e53db738bb1727399b60f67140baf9f307fbc98 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Thu, 19 Mar 2026 01:10:09 +0100 Subject: [PATCH 08/13] fix: revert to old mlkit commit to fix broken dependecies and dataloading --- pyproject.toml | 4 - .../callbacks/wsi_assembler.py | 20 +- .../data/datasets/predict_dataset.py | 14 +- .../data/datasets/test_dataset.py | 14 +- .../data/datasets/train_dataset.py | 12 +- .../stain_normalization_model.py | 8 +- uv.lock | 1577 ++++++++--------- 7 files changed, 764 insertions(+), 885 deletions(-) diff --git a/pyproject.toml b/pyproject.toml index 4fcfaf2..0603a03 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -26,7 +26,3 @@ dev = ["mypy", "ruff"] [tool.mypy] ignore_missing_imports = true -[tool.uv] -environments = ["sys_platform == 'linux'"] - -override-dependencies = ["mlflow>=2.15.1"] diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py index fbf6d7f..677bfe7 100644 --- a/stain_normalization/callbacks/wsi_assembler.py +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -61,18 +61,18 @@ def on_predict_start(self, trainer: Trainer, pl_module: LightningModule) -> None def on_predict_dataloader_start( self, trainer: Trainer, pl_module: LightningModule, dataloader_idx: int ) -> None: - slide = trainer.datamodule.predict.slides[dataloader_idx] # type: ignore[attr-defined] + slide = trainer.datamodule.predict.slides.iloc[dataloader_idx] # type: ignore[attr-defined] meta = _SlideMeta( - path=slide["path"], - level=int(slide["level"]), - extent_x=int(slide["extent_x"]), - extent_y=int(slide["extent_y"]), - tile_extent_x=int(slide["tile_extent_x"]), - tile_extent_y=int(slide["tile_extent_y"]), - mpp_x=float(slide["mpp_x"]), - mpp_y=float(slide["mpp_y"]), + path=slide.path, + level=int(slide.level), + extent_x=int(slide.extent_x), + extent_y=int(slide.extent_y), + tile_extent_x=int(slide.tile_extent_x), + tile_extent_y=int(slide.tile_extent_y), + mpp_x=float(slide.mpp_x), + mpp_y=float(slide.mpp_y), ) - slide_name = Path(slide["path"]).stem + slide_name = Path(slide.path).stem self._open_slide(slide_name, meta) def on_predict_dataloader_end( diff --git a/stain_normalization/data/datasets/predict_dataset.py b/stain_normalization/data/datasets/predict_dataset.py index a35ad86..aba3372 100644 --- a/stain_normalization/data/datasets/predict_dataset.py +++ b/stain_normalization/data/datasets/predict_dataset.py @@ -35,7 +35,7 @@ def generate_datasets(self) -> Iterable[Dataset[PredictSample]]: tiles=self.filter_tiles_by_slide(slide["id"]), normalize=self.normalize, ) - for slide in self.slides + for _, slide in self.slides.iterrows() ) @@ -48,10 +48,10 @@ def __init__( ) -> None: super().__init__() self.slide_tiles = OpenSlideTilesDataset( - slide_path=slide_metadata["path"], - level=slide_metadata["level"], - tile_extent_x=slide_metadata["tile_extent_x"], - tile_extent_y=slide_metadata["tile_extent_y"], + slide_path=slide_metadata.path, + level=slide_metadata.level, + tile_extent_x=slide_metadata.tile_extent_x, + tile_extent_y=slide_metadata.tile_extent_y, tiles=tiles, ) @@ -64,8 +64,8 @@ def __len__(self) -> int: def __getitem__(self, idx: int) -> PredictSample: input_image_255 = self.slide_tiles[idx] slide_name = self.slide_tiles.slide_path.stem - tile = self.slide_tiles.tiles[idx] - x, y = tile["x"], tile["y"] + x = self.slide_tiles.tiles.iloc[idx]["x"] + y = self.slide_tiles.tiles.iloc[idx]["y"] input_image = input_image_255 / 255.0 diff --git a/stain_normalization/data/datasets/test_dataset.py b/stain_normalization/data/datasets/test_dataset.py index f636c04..5a536b0 100644 --- a/stain_normalization/data/datasets/test_dataset.py +++ b/stain_normalization/data/datasets/test_dataset.py @@ -40,7 +40,7 @@ def generate_datasets(self) -> Iterable[Dataset[PredictSample]]: modify=self.modify, normalize=self.normalize, ) - for slide in self.slides + for _, slide in self.slides.iterrows() ) @@ -54,10 +54,10 @@ def __init__( ) -> None: super().__init__() self.slide_tiles = OpenSlideTilesDataset( - slide_path=slide_metadata["path"], - level=slide_metadata["level"], - tile_extent_x=slide_metadata["tile_extent_x"], - tile_extent_y=slide_metadata["tile_extent_y"], + slide_path=slide_metadata.path, + level=slide_metadata.level, + tile_extent_x=slide_metadata.tile_extent_x, + tile_extent_y=slide_metadata.tile_extent_y, tiles=tiles, ) self.modify = modify @@ -70,8 +70,8 @@ def __len__(self) -> int: def __getitem__(self, idx: int) -> PredictSample: original_image_255 = self.slide_tiles[idx] slide_name = self.slide_tiles.slide_path.stem - tile = self.slide_tiles.tiles[idx] - x, y = tile["x"], tile["y"] + x = self.slide_tiles.tiles.iloc[idx]["x"] + y = self.slide_tiles.tiles.iloc[idx]["y"] # Create "wrong" image to use as input. 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= "3.23.0" From 240856f800b75ddc119cfc25ee3b97a02eae92fc Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Fri, 20 Mar 2026 03:12:02 +0100 Subject: [PATCH 09/13] feat: add torchmetrics-based evaluation --- configs/default.yaml | 3 +- pyproject.toml | 1 + stain_normalization/metrics/__init__.py | 16 ++ stain_normalization/metrics/torch_metrics.py | 176 ++++++++++++++++++ .../stain_normalization_model.py | 28 ++- uv.lock | 53 +++++- 6 files changed, 266 insertions(+), 11 deletions(-) create mode 100644 stain_normalization/metrics/torch_metrics.py diff --git a/configs/default.yaml b/configs/default.yaml index 5944109..6f83fa6 100644 --- a/configs/default.yaml +++ b/configs/default.yaml @@ -50,6 +50,8 @@ model: lambda_l1: 0.2 lambda_lum: 0.2 lambda_gdl: 0.1 + normalize_mean: ${data.test.normalize.mean} + normalize_std: ${data.test.normalize.std} trainer: enable_checkpointing: True @@ -60,7 +62,6 @@ trainer: callbacks: - ${callbacks.model_checkpoint} - ${callbacks.early_stopping} - - ${callbacks.analysis_export} data: batch_size: 64 diff --git a/pyproject.toml b/pyproject.toml index 0603a03..c97f229 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -18,6 +18,7 @@ dependencies = [ "scikit-image>=0.25.2", "rationai-staining @ git+https://gitlab.ics.muni.cz/rationai/digital-pathology/libraries/staining.git", "openslide-python>=1.4.3", + "kornia>=0.8.2", ] [dependency-groups] diff --git a/stain_normalization/metrics/__init__.py b/stain_normalization/metrics/__init__.py index 8153500..9a8f80d 100644 --- a/stain_normalization/metrics/__init__.py +++ b/stain_normalization/metrics/__init__.py @@ -1,16 +1,32 @@ from stain_normalization.metrics.image_metrics import ( compute_lab_brightness_psnr, + compute_mean_brightness, compute_nmi, compute_pcc, ) +from stain_normalization.metrics.torch_metrics import ( + MeanBrightness, + MeanEosinDistance, + MeanHematoxylinDistance, + MeanLabPSNR, + + MeanPCC, +) from stain_normalization.metrics.vector_metrics import ( compare_vectors, ) __all__ = [ + "MeanBrightness", + "MeanEosinDistance", + "MeanHematoxylinDistance", + "MeanLabPSNR", + "MeanNMI", + "MeanPCC", "compare_vectors", "compute_lab_brightness_psnr", + "compute_mean_brightness", "compute_nmi", "compute_pcc", ] diff --git a/stain_normalization/metrics/torch_metrics.py b/stain_normalization/metrics/torch_metrics.py new file mode 100644 index 0000000..5d590e2 --- /dev/null +++ b/stain_normalization/metrics/torch_metrics.py @@ -0,0 +1,176 @@ +import numpy as np +import torch +from kornia.color import rgb_to_lab +from rationai.staining import estimate_stain_vectors +from torch import Tensor +from torchmetrics import Metric +from torchmetrics.functional.image import peak_signal_noise_ratio + +from stain_normalization.metrics.vector_metrics import compare_vectors + + +def _tensor_to_uint8(tensor: Tensor) -> np.ndarray: + """Convert CHW [0,1] tensor to HWC uint8 numpy array.""" + return (tensor.clamp(0, 1).permute(1, 2, 0).cpu().numpy() * 255).astype(np.uint8) + + +class _DenormalizingMetric(Metric): + """Base class for metrics that need denormalized [0,1] images. + + If denormalize_mean/std are None, assumes input is already in [0,1] range. + """ + + def __init__( + self, + denormalize_mean: list[float] | None = None, + denormalize_std: list[float] | None = None, + ) -> None: + super().__init__() + if denormalize_mean is not None and denormalize_std is not None: + self.register_buffer( + "denorm_mean", torch.tensor(denormalize_mean).view(3, 1, 1) + ) + self.register_buffer( + "denorm_std", torch.tensor(denormalize_std).view(3, 1, 1) + ) + else: + self.register_buffer("denorm_mean", None) + self.register_buffer("denorm_std", None) + + def _denormalize(self, tensor: Tensor) -> Tensor: + if self.denorm_mean is None: + return tensor + return tensor * self.denorm_std.to(tensor.device) + self.denorm_mean.to(tensor.device) + + +# --- Stain vector metrics (numpy-based) --- + + +class _BaseStainDistance(_DenormalizingMetric): + """Base class for stain vector distance metrics. + + Converts tensors to numpy for stain vector estimation. + """ + + def __init__(self, denormalize_mean: list[float], denormalize_std: list[float]) -> None: + super().__init__(denormalize_mean, denormalize_std) + self.add_state("distance_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") + + def _stain_key(self) -> str: + raise NotImplementedError + + def update(self, preds: Tensor, target: Tensor) -> None: + key = self._stain_key() + for i in range(preds.shape[0]): + pred_np = _tensor_to_uint8(self._denormalize(preds[i])) + target_np = _tensor_to_uint8(self._denormalize(target[i])) + + pred_vecs = estimate_stain_vectors(pred_np) + target_vecs = estimate_stain_vectors(target_np) + + result = compare_vectors(target_vecs, pred_vecs) + + if not np.isnan(result[key]): + self.distance_sum += result[key] + self.count += 1 + + def compute(self) -> Tensor: + if self.count == 0: + return torch.tensor(float("nan")) + return self.distance_sum / self.count + + +class MeanHematoxylinDistance(_BaseStainDistance): + """Mean CIE76 Delta E for hematoxylin stain vectors.""" + + def _stain_key(self) -> str: + return "d_hematoxylin" + + +class MeanEosinDistance(_BaseStainDistance): + """Mean CIE76 Delta E for eosin stain vectors.""" + + def _stain_key(self) -> str: + return "d_eosin" + + +class MeanBrightness(_DenormalizingMetric): + """Mean L* brightness in CIE Lab color space. + + Uses kornia for GPU-based RGB to Lab conversion. + """ + + def __init__(self, denormalize_mean: list[float], denormalize_std: list[float]) -> None: + super().__init__(denormalize_mean, denormalize_std) + self.add_state("brightness_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") + + def update(self, preds: Tensor, target: Tensor) -> None: + denormed = self._denormalize(preds).clamp(0, 1) + lab = rgb_to_lab(denormed) + self.brightness_sum += lab[:, 0].mean() + self.count += 1 + + def compute(self) -> Tensor: + if self.count == 0: + return torch.tensor(float("nan")) + return self.brightness_sum / self.count + + +class MeanLabPSNR(_DenormalizingMetric): + """Mean PSNR on the L* channel in CIE Lab color space. + + Uses kornia for GPU-based RGB to Lab conversion, + torchmetrics for PSNR computation. + """ + + def __init__(self, denormalize_mean: list[float], denormalize_std: list[float]) -> None: + super().__init__(denormalize_mean, denormalize_std) + self.add_state("psnr_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") + + def update(self, preds: Tensor, target: Tensor) -> None: + pred_lab = rgb_to_lab(self._denormalize(preds).clamp(0, 1)) + target_lab = rgb_to_lab(self._denormalize(target).clamp(0, 1)) + + # L channel: BxHxW, data_range=100.0 + pred_l = pred_lab[:, 0:1] + target_l = target_lab[:, 0:1] + + self.psnr_sum += peak_signal_noise_ratio(pred_l, target_l, data_range=100.0) + self.count += 1 + + def compute(self) -> Tensor: + if self.count == 0: + return torch.tensor(float("nan")) + return self.psnr_sum / self.count + + +class MeanPCC(Metric): + """Mean Pearson Correlation Coefficient between image pairs. + + Operates on raw normalized tensors (no denormalization needed). + """ + + def __init__(self) -> None: + super().__init__() + self.add_state("pcc_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") + + def update(self, preds: Tensor, target: Tensor) -> None: + for i in range(preds.shape[0]): + x = preds[i].flatten().float() + y = target[i].flatten().float() + + if x.std() == 0 or y.std() == 0: + continue + + pcc = torch.corrcoef(torch.stack([x, y]))[0, 1] + self.pcc_sum += pcc + self.count += 1 + + def compute(self) -> Tensor: + if self.count == 0: + return torch.tensor(float("nan")) + return self.pcc_sum / self.count diff --git a/stain_normalization/stain_normalization_model.py b/stain_normalization/stain_normalization_model.py index 3c09941..caea590 100644 --- a/stain_normalization/stain_normalization_model.py +++ b/stain_normalization/stain_normalization_model.py @@ -6,6 +6,13 @@ from torchmetrics.image import StructuralSimilarityIndexMeasure from torchmetrics.regression import MeanAbsoluteError +from stain_normalization.metrics.torch_metrics import ( + MeanBrightness, + MeanEosinDistance, + MeanHematoxylinDistance, + MeanLabPSNR, + MeanPCC, +) from stain_normalization.modeling import L1SSIMLoss, UNet from stain_normalization.type_aliases import Batch, Outputs, PredictBatch @@ -18,6 +25,8 @@ def __init__( lambda_l1: float = 0.2, lambda_lum: float = 0.2, lambda_gdl: float = 0.1, + normalize_mean: list[float] | None = None, + normalize_std: list[float] | None = None, ) -> None: super().__init__() self.lr = lr @@ 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} dependencies = [ { name = "albumentations" }, + { name = "kornia" }, { name = "lightning" }, { name = "openslide-python" }, { name = "rationai-masks" }, @@ -2333,6 +2371,7 @@ dev = [ [package.metadata] requires-dist = [ { name = "albumentations", specifier = ">=1.4.14" }, + { name = "kornia", specifier = ">=0.8.2" }, { name = "lightning", specifier = ">=2.0.0" }, { name = "openslide-python", specifier = ">=1.4.3" }, { name = "rationai-masks", git = "https://gitlab.ics.muni.cz/rationai/digital-pathology/libraries/masks.git" }, From 2befe198160d245b6abf8bd631e56306df5a7fee Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Fri, 20 Mar 2026 03:26:58 +0100 Subject: [PATCH 10/13] chore: mypy and ruff formating --- stain_normalization/metrics/__init__.py | 1 - stain_normalization/metrics/torch_metrics.py | 40 ++++++++++++++++--- .../stain_normalization_model.py | 9 ++--- 3 files changed, 38 insertions(+), 12 deletions(-) diff --git a/stain_normalization/metrics/__init__.py b/stain_normalization/metrics/__init__.py index 9a8f80d..4d2a405 100644 --- a/stain_normalization/metrics/__init__.py +++ b/stain_normalization/metrics/__init__.py @@ -9,7 +9,6 @@ MeanEosinDistance, MeanHematoxylinDistance, MeanLabPSNR, - MeanPCC, ) from stain_normalization.metrics.vector_metrics import ( diff --git a/stain_normalization/metrics/torch_metrics.py b/stain_normalization/metrics/torch_metrics.py index 5d590e2..dffa8df 100644 --- a/stain_normalization/metrics/torch_metrics.py +++ b/stain_normalization/metrics/torch_metrics.py @@ -40,7 +40,9 @@ def __init__( def _denormalize(self, tensor: Tensor) -> Tensor: if self.denorm_mean is None: return tensor - return tensor * self.denorm_std.to(tensor.device) + self.denorm_mean.to(tensor.device) + mean: Tensor = self.denorm_mean # type: ignore[assignment] + std: Tensor = self.denorm_std # type: ignore[assignment] + return tensor * std.to(tensor.device) + mean.to(tensor.device) # --- Stain vector metrics (numpy-based) --- @@ -52,7 +54,14 @@ class _BaseStainDistance(_DenormalizingMetric): Converts tensors to numpy for stain vector estimation. """ - def __init__(self, denormalize_mean: list[float], denormalize_std: list[float]) -> None: + distance_sum: Tensor + count: Tensor + + def __init__( + self, + denormalize_mean: list[float] | None = None, + denormalize_std: list[float] | None = None, + ) -> None: super().__init__(denormalize_mean, denormalize_std) self.add_state("distance_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") @@ -101,14 +110,23 @@ class MeanBrightness(_DenormalizingMetric): Uses kornia for GPU-based RGB to Lab conversion. """ - def __init__(self, denormalize_mean: list[float], denormalize_std: list[float]) -> None: + brightness_sum: Tensor + count: Tensor + + def __init__( + self, + denormalize_mean: list[float] | None = None, + denormalize_std: list[float] | None = None, + ) -> None: super().__init__(denormalize_mean, denormalize_std) - self.add_state("brightness_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state( + "brightness_sum", default=torch.tensor(0.0), dist_reduce_fx="sum" + ) self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: denormed = self._denormalize(preds).clamp(0, 1) - lab = rgb_to_lab(denormed) + lab = rgb_to_lab(denormed) self.brightness_sum += lab[:, 0].mean() self.count += 1 @@ -125,7 +143,14 @@ class MeanLabPSNR(_DenormalizingMetric): torchmetrics for PSNR computation. """ - def __init__(self, denormalize_mean: list[float], denormalize_std: list[float]) -> None: + psnr_sum: Tensor + count: Tensor + + def __init__( + self, + denormalize_mean: list[float] | None = None, + denormalize_std: list[float] | None = None, + ) -> None: super().__init__(denormalize_mean, denormalize_std) self.add_state("psnr_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") @@ -153,6 +178,9 @@ class MeanPCC(Metric): Operates on raw normalized tensors (no denormalization needed). """ + pcc_sum: Tensor + count: Tensor + def __init__(self) -> None: super().__init__() self.add_state("pcc_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") diff --git a/stain_normalization/stain_normalization_model.py b/stain_normalization/stain_normalization_model.py index caea590..2655040 100644 --- a/stain_normalization/stain_normalization_model.py +++ b/stain_normalization/stain_normalization_model.py @@ -43,16 +43,15 @@ def __init__( ) self.val_metrics = val_metrics.clone(prefix="validation/") - denorm = dict(denormalize_mean=normalize_mean, denormalize_std=normalize_std) self.test_metrics = MetricCollection( { "ssim": StructuralSimilarityIndexMeasure(), "l1": MeanAbsoluteError(), "pcc": MeanPCC(), - "d_hematoxylin": MeanHematoxylinDistance(**denorm), - "d_eosin": MeanEosinDistance(**denorm), - "brightness": MeanBrightness(**denorm), - "lab_psnr": MeanLabPSNR(**denorm), + "d_hematoxylin": MeanHematoxylinDistance(normalize_mean, normalize_std), + "d_eosin": MeanEosinDistance(normalize_mean, normalize_std), + "brightness": MeanBrightness(normalize_mean, normalize_std), + "lab_psnr": MeanLabPSNR(normalize_mean, normalize_std), }, prefix="test/", ) From 69ca0e3e225e2d6f74d9157e07bd4a3e3e372397 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Sat, 21 Mar 2026 23:37:44 +0100 Subject: [PATCH 11/13] fix: review feedback --- stain_normalization/metrics/__init__.py | 7 +- stain_normalization/metrics/torch_metrics.py | 144 ++++++------------ .../stain_normalization_model.py | 34 ++++- 3 files changed, 74 insertions(+), 111 deletions(-) diff --git a/stain_normalization/metrics/__init__.py b/stain_normalization/metrics/__init__.py index 4d2a405..5ee0e61 100644 --- a/stain_normalization/metrics/__init__.py +++ b/stain_normalization/metrics/__init__.py @@ -6,10 +6,9 @@ ) from stain_normalization.metrics.torch_metrics import ( MeanBrightness, - MeanEosinDistance, - MeanHematoxylinDistance, MeanLabPSNR, MeanPCC, + MeanStainDistance, ) from stain_normalization.metrics.vector_metrics import ( compare_vectors, @@ -18,11 +17,9 @@ __all__ = [ "MeanBrightness", - "MeanEosinDistance", - "MeanHematoxylinDistance", "MeanLabPSNR", - "MeanNMI", "MeanPCC", + "MeanStainDistance", "compare_vectors", "compute_lab_brightness_psnr", "compute_mean_brightness", diff --git a/stain_normalization/metrics/torch_metrics.py b/stain_normalization/metrics/torch_metrics.py index dffa8df..d541b88 100644 --- a/stain_normalization/metrics/torch_metrics.py +++ b/stain_normalization/metrics/torch_metrics.py @@ -14,119 +14,70 @@ def _tensor_to_uint8(tensor: Tensor) -> np.ndarray: return (tensor.clamp(0, 1).permute(1, 2, 0).cpu().numpy() * 255).astype(np.uint8) -class _DenormalizingMetric(Metric): - """Base class for metrics that need denormalized [0,1] images. +class MeanStainDistance(Metric): + """Mean CIE76 Delta E for hematoxylin and eosin stain vectors. - If denormalize_mean/std are None, assumes input is already in [0,1] range. + Expects denormalized [0,1] tensors. Converts to numpy for stain vector estimation. """ - def __init__( - self, - denormalize_mean: list[float] | None = None, - denormalize_std: list[float] | None = None, - ) -> None: - super().__init__() - if denormalize_mean is not None and denormalize_std is not None: - self.register_buffer( - "denorm_mean", torch.tensor(denormalize_mean).view(3, 1, 1) - ) - self.register_buffer( - "denorm_std", torch.tensor(denormalize_std).view(3, 1, 1) - ) - else: - self.register_buffer("denorm_mean", None) - self.register_buffer("denorm_std", None) - - def _denormalize(self, tensor: Tensor) -> Tensor: - if self.denorm_mean is None: - return tensor - mean: Tensor = self.denorm_mean # type: ignore[assignment] - std: Tensor = self.denorm_std # type: ignore[assignment] - return tensor * std.to(tensor.device) + mean.to(tensor.device) - - -# --- Stain vector metrics (numpy-based) --- - - -class _BaseStainDistance(_DenormalizingMetric): - """Base class for stain vector distance metrics. - - Converts tensors to numpy for stain vector estimation. - """ + h_sum: Tensor + h_count: Tensor + e_sum: Tensor + e_count: Tensor - distance_sum: Tensor - count: Tensor - - def __init__( - self, - denormalize_mean: list[float] | None = None, - denormalize_std: list[float] | None = None, - ) -> None: - super().__init__(denormalize_mean, denormalize_std) - self.add_state("distance_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") - self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") - - def _stain_key(self) -> str: - raise NotImplementedError + def __init__(self) -> None: + super().__init__() + self.add_state("h_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state("h_count", default=torch.tensor(0), dist_reduce_fx="sum") + self.add_state("e_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") + self.add_state("e_count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: - key = self._stain_key() for i in range(preds.shape[0]): - pred_np = _tensor_to_uint8(self._denormalize(preds[i])) - target_np = _tensor_to_uint8(self._denormalize(target[i])) + pred_np = _tensor_to_uint8(preds[i]) + target_np = _tensor_to_uint8(target[i]) pred_vecs = estimate_stain_vectors(pred_np) target_vecs = estimate_stain_vectors(target_np) result = compare_vectors(target_vecs, pred_vecs) - if not np.isnan(result[key]): - self.distance_sum += result[key] - self.count += 1 - - def compute(self) -> Tensor: - if self.count == 0: - return torch.tensor(float("nan")) - return self.distance_sum / self.count - - -class MeanHematoxylinDistance(_BaseStainDistance): - """Mean CIE76 Delta E for hematoxylin stain vectors.""" - - def _stain_key(self) -> str: - return "d_hematoxylin" - - -class MeanEosinDistance(_BaseStainDistance): - """Mean CIE76 Delta E for eosin stain vectors.""" - - def _stain_key(self) -> str: - return "d_eosin" - - -class MeanBrightness(_DenormalizingMetric): + if not np.isnan(result["d_hematoxylin"]): + self.h_sum += result["d_hematoxylin"] + self.h_count += 1 + if not np.isnan(result["d_eosin"]): + self.e_sum += result["d_eosin"] + self.e_count += 1 + + def compute(self) -> dict[str, Tensor]: + return { + "d_hematoxylin": self.h_sum / self.h_count + if self.h_count > 0 + else torch.tensor(float("nan")), + "d_eosin": self.e_sum / self.e_count + if self.e_count > 0 + else torch.tensor(float("nan")), + } + + +class MeanBrightness(Metric): """Mean L* brightness in CIE Lab color space. - Uses kornia for GPU-based RGB to Lab conversion. + Expects denormalized [0,1] tensors. Uses kornia for GPU-based RGB to Lab conversion. """ brightness_sum: Tensor count: Tensor - def __init__( - self, - denormalize_mean: list[float] | None = None, - denormalize_std: list[float] | None = None, - ) -> None: - super().__init__(denormalize_mean, denormalize_std) + def __init__(self) -> None: + super().__init__() self.add_state( "brightness_sum", default=torch.tensor(0.0), dist_reduce_fx="sum" ) self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: - denormed = self._denormalize(preds).clamp(0, 1) - lab = rgb_to_lab(denormed) + lab = rgb_to_lab(preds.clamp(0, 1)) self.brightness_sum += lab[:, 0].mean() self.count += 1 @@ -136,30 +87,25 @@ def compute(self) -> Tensor: return self.brightness_sum / self.count -class MeanLabPSNR(_DenormalizingMetric): +class MeanLabPSNR(Metric): """Mean PSNR on the L* channel in CIE Lab color space. - Uses kornia for GPU-based RGB to Lab conversion, + Expects denormalized [0,1] tensors. Uses kornia for RGB to Lab conversion, torchmetrics for PSNR computation. """ psnr_sum: Tensor count: Tensor - def __init__( - self, - denormalize_mean: list[float] | None = None, - denormalize_std: list[float] | None = None, - ) -> None: - super().__init__(denormalize_mean, denormalize_std) + def __init__(self) -> None: + super().__init__() self.add_state("psnr_sum", default=torch.tensor(0.0), dist_reduce_fx="sum") self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: - pred_lab = rgb_to_lab(self._denormalize(preds).clamp(0, 1)) - target_lab = rgb_to_lab(self._denormalize(target).clamp(0, 1)) + pred_lab = rgb_to_lab(preds.clamp(0, 1)) + target_lab = rgb_to_lab(target.clamp(0, 1)) - # L channel: BxHxW, data_range=100.0 pred_l = pred_lab[:, 0:1] target_l = target_lab[:, 0:1] @@ -175,7 +121,7 @@ def compute(self) -> Tensor: class MeanPCC(Metric): """Mean Pearson Correlation Coefficient between image pairs. - Operates on raw normalized tensors (no denormalization needed). + Operates on raw tensors (no denormalization needed). """ pcc_sum: Tensor diff --git a/stain_normalization/stain_normalization_model.py b/stain_normalization/stain_normalization_model.py index 2655040..ff51b98 100644 --- a/stain_normalization/stain_normalization_model.py +++ b/stain_normalization/stain_normalization_model.py @@ -6,12 +6,13 @@ from torchmetrics.image import StructuralSimilarityIndexMeasure from torchmetrics.regression import MeanAbsoluteError +import torch + from stain_normalization.metrics.torch_metrics import ( MeanBrightness, - MeanEosinDistance, - MeanHematoxylinDistance, MeanLabPSNR, MeanPCC, + MeanStainDistance, ) from stain_normalization.modeling import L1SSIMLoss, UNet from stain_normalization.type_aliases import Batch, Outputs, PredictBatch @@ -38,6 +39,17 @@ def __init__( lambda_gdl=lambda_gdl, ) + if normalize_mean is not None and normalize_std is not None: + self.register_buffer( + "_denorm_mean", torch.tensor(normalize_mean).view(1, 3, 1, 1) + ) + self.register_buffer( + "_denorm_std", torch.tensor(normalize_std).view(1, 3, 1, 1) + ) + else: + self.register_buffer("_denorm_mean", None) + self.register_buffer("_denorm_std", None) + val_metrics = MetricCollection( {"ssim": StructuralSimilarityIndexMeasure(), "l1": MeanAbsoluteError()} ) @@ -48,10 +60,9 @@ def __init__( "ssim": StructuralSimilarityIndexMeasure(), "l1": MeanAbsoluteError(), "pcc": MeanPCC(), - "d_hematoxylin": MeanHematoxylinDistance(normalize_mean, normalize_std), - "d_eosin": MeanEosinDistance(normalize_mean, normalize_std), - "brightness": MeanBrightness(normalize_mean, normalize_std), - "lab_psnr": MeanLabPSNR(normalize_mean, normalize_std), + "stain": MeanStainDistance(), + "brightness": MeanBrightness(), + "lab_psnr": MeanLabPSNR(), }, prefix="test/", ) @@ -59,6 +70,13 @@ def __init__( def forward(self, x: Tensor) -> Outputs: return self.unet(x) + def _denormalize(self, tensor: Tensor) -> Tensor: + if self._denorm_mean is None: + return tensor + mean: Tensor = self._denorm_mean # type: ignore[assignment] + std: Tensor = self._denorm_std # type: ignore[assignment] + return tensor * std + mean + def training_step(self, batch: Batch) -> Tensor: inputs, targets = batch outputs = self(inputs) @@ -89,7 +107,9 @@ def test_step( targets = stack([item["original_image_tensor"] for item in data]).to( outputs.device ) - self.test_metrics.update(outputs, targets) + denormed_outputs = self._denormalize(outputs) + denormed_targets = self._denormalize(targets) + self.test_metrics.update(denormed_outputs, denormed_targets) self.log_dict( self.test_metrics, batch_size=len(inputs), From cbc5a6c84473d3b4ffeb6a338a867c50b9eb6be1 Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Fri, 27 Mar 2026 01:44:40 +0100 Subject: [PATCH 12/13] fix: review feedback --- configs/default.yaml | 3 - stain_normalization/analysis/__init__.py | 6 - stain_normalization/analysis/analyzer.py | 232 ------------------ stain_normalization/callbacks/__init__.py | 4 +- stain_normalization/callbacks/_base.py | 31 +-- .../callbacks/analysis_export.py | 59 ----- stain_normalization/callbacks/tiles_export.py | 8 +- .../callbacks/wsi_assembler.py | 9 +- stain_normalization/data/data_module.py | 17 +- stain_normalization/metrics/torch_metrics.py | 30 +-- .../stain_normalization_model.py | 38 ++- 11 files changed, 53 insertions(+), 384 deletions(-) delete mode 100644 stain_normalization/analysis/__init__.py delete mode 100644 stain_normalization/analysis/analyzer.py delete mode 100644 stain_normalization/callbacks/analysis_export.py diff --git a/configs/default.yaml b/configs/default.yaml index 6f83fa6..3351f93 100644 --- a/configs/default.yaml +++ b/configs/default.yaml @@ -24,19 +24,16 @@ callbacks: tiles_export: _target_: stain_normalization.callbacks.TilesExport output_dir: ${output_dir} - normalization_config: ${data.test.normalize} n_first: 10 sample_rate: 0.0005 # for test dataset cca 100 tiles analysis_export: _target_: stain_normalization.callbacks.AnalysisExport output_dir: ${output_dir} - normalization_config: ${data.test.normalize} wsi_assembler: _target_: stain_normalization.callbacks.WSIAssembler output_dir: ${output_dir} - normalization_config: ${data.predict.normalize} early_stopping: _target_: lightning.pytorch.callbacks.EarlyStopping diff --git a/stain_normalization/analysis/__init__.py b/stain_normalization/analysis/__init__.py deleted file mode 100644 index 16504d5..0000000 --- a/stain_normalization/analysis/__init__.py +++ /dev/null @@ -1,6 +0,0 @@ -from stain_normalization.analysis.analyzer import StainAnalyzer - - -__all__ = [ - "StainAnalyzer", -] diff --git a/stain_normalization/analysis/analyzer.py b/stain_normalization/analysis/analyzer.py deleted file mode 100644 index 1118013..0000000 --- a/stain_normalization/analysis/analyzer.py +++ /dev/null @@ -1,232 +0,0 @@ -"""Stain normalization analysis tool. - -Compares images using selected metrics, accumulates results, -and provides statistics and saving. -""" - -from pathlib import Path -from typing import Any, ClassVar - -import numpy as np -import pandas as pd -from rationai.staining import estimate_stain_vectors -from skimage.metrics import structural_similarity - -from stain_normalization.metrics.image_metrics import ( - compute_lab_brightness_psnr, - compute_mean_brightness, - compute_nmi, - compute_pcc, -) -from stain_normalization.metrics.vector_metrics import compare_vectors - - -class StainAnalyzer: - """Compare images using selected metrics, accumulate results. - - Args: - reference: Optional fixed reference image. If given, stain vectors, - NMI, and mean brightness are pre-computed once. - metrics: Which metrics to compute. None or [] = all. - """ - - AVAILABLE_METRICS: ClassVar[list[str]] = [ - "vectors", - "ssim", - "pcc", - "nmi", - "lab_psnr", - "mean_brightness", - ] - PAIRED_ONLY: ClassVar[set[str]] = {"ssim", "pcc", "lab_psnr"} - - def __init__( - self, - reference: np.ndarray[Any, Any] | None = None, - metrics: list[str] | None = None, - ) -> None: - self.metrics = metrics or self.AVAILABLE_METRICS - self._results: list[dict[str, Any]] = [] - - for m in self.metrics: - if m not in self.AVAILABLE_METRICS: - raise ValueError( - f"Unknown metric '{m}'. Available: {self.AVAILABLE_METRICS}" - ) - - # if we have reference image, precompute stain vectors, NMI, and brightness - self._ref_img = reference - self._ref_vectors = None - self._ref_nmi = None - self._ref_brightness = None - - if reference is not None: - if "vectors" in self.metrics: - self._ref_vectors = estimate_stain_vectors(reference) - if np.isnan(self._ref_vectors).any(): - raise ValueError( - "Reference image has too much background; no valid stain vectors found." - ) - if "nmi" in self.metrics: - self._ref_nmi = compute_nmi(reference) - if "mean_brightness" in self.metrics: - self._ref_brightness = compute_mean_brightness(reference) - - @property - def results(self) -> pd.DataFrame: - """Accumulated comparison results as DataFrame.""" - return pd.DataFrame(self._results) - - def clear(self) -> None: - """Clear accumulated results.""" - self._results.clear() - - def compare( - self, - image: np.ndarray[Any, Any], - image_id: str | None = None, - paired_image: np.ndarray[Any, Any] | None = None, - ) -> dict[str, Any]: - """Compare an image against the reference and store the result. - - Args: - image: Image to compare. - image_id: Optional identifier for this comparison. - paired_image: Paired original image for this specific tile. - When provided, structural metrics (SSIM, PCC, Lab PSNR) are computed. - - Returns: - Dict with metric results. - """ - ref_img = paired_image if paired_image is not None else self._ref_img - if ref_img is None: - raise ValueError( - "No reference image. Pass one to __init__ or to compare()." - ) - - is_paired = paired_image is not None - - if paired_image is not None: - ref_vectors = ( - estimate_stain_vectors(ref_img) if "vectors" in self.metrics else None - ) - ref_nmi = compute_nmi(ref_img) if "nmi" in self.metrics else None - ref_brightness = ( - compute_mean_brightness(ref_img) - if "mean_brightness" in self.metrics - else None - ) - else: - ref_vectors = self._ref_vectors - ref_nmi = self._ref_nmi - ref_brightness = self._ref_brightness - - result: dict[str, Any] = {"id": image_id} if image_id is not None else {} - - if "vectors" in self.metrics and ref_vectors is not None: - # ref_vectors can be None for paired tiles with too much background - img_vectors = estimate_stain_vectors(image) - vec_result = compare_vectors(ref_vectors, img_vectors) - result.update(vec_result) - img_vectors_paired = ( - img_vectors[[1, 0]] if vec_result["was_swapped"] else img_vectors - ) - for j, val in enumerate(ref_vectors.flatten()): - result[f"ref_vec_{j}"] = float(val) - for j, val in enumerate(img_vectors_paired.flatten()): - result[f"img_vec_{j}"] = float(val) - - if "ssim" in self.metrics and is_paired: - result["ssim"] = float( - structural_similarity( - ref_img, - image, - channel_axis=-1, - data_range=255, - ) - ) - - if "pcc" in self.metrics and is_paired: - result["pcc"] = compute_pcc(ref_img, image) - - if "nmi" in self.metrics: - assert ref_nmi is not None - img_nmi = compute_nmi(image) - result["ref_nmi"] = ref_nmi - result["nmi"] = img_nmi - result["nmi_diff"] = img_nmi - ref_nmi - - if "lab_psnr" in self.metrics and is_paired: - result["lab_brightness_psnr"] = compute_lab_brightness_psnr(ref_img, image) - - if "mean_brightness" in self.metrics: - assert ref_brightness is not None - img_brightness = compute_mean_brightness(image) - result["ref_mean_brightness"] = ref_brightness - result["mean_brightness"] = img_brightness - result["mean_brightness_diff"] = img_brightness - ref_brightness - - self._results.append(result) - return result - - # --- Statistics --- - - def get_statistics(self) -> pd.DataFrame: - """Summary statistics for accumulated results. - - Returns: - DataFrame with mean, std, min, max, percentiles. - """ - df = self.results - numeric_cols = df.select_dtypes(include=[np.number]).columns - if df.empty or len(numeric_cols) == 0: - return pd.DataFrame() - return df[numeric_cols].describe(percentiles=[0.05, 0.25, 0.5, 0.75, 0.95]) - - def get_baseline_ranges( - self, - percentile_low: float = 5, - percentile_high: float = 95, - ) -> dict[str, tuple[float, float]]: - """Get acceptable value ranges for each metric. - - Args: - percentile_low: Lower percentile bound. Defaults to 5. - percentile_high: Upper percentile bound. Defaults to 95. - - Returns: - Dict mapping metric names to (low, high) tuples. - """ - df = self.results - numeric_cols = df.select_dtypes(include=[np.number]).columns - return { - col: ( - float(df[col].quantile(percentile_low / 100)), - float(df[col].quantile(percentile_high / 100)), - ) - for col in numeric_cols - } - - def save_csv(self, output_dir: str | Path) -> Path: - """Save accumulated results and statistics as CSV files. - - Args: - output_dir: Directory to save files into. - - Returns: - Path to the output directory. - """ - output_dir = Path(output_dir) - output_dir.mkdir(parents=True, exist_ok=True) - - self.results.to_csv(output_dir / "results.csv", index=True) - self.get_statistics().to_csv(output_dir / "statistics.csv") - - ranges = self.get_baseline_ranges() - with open(output_dir / "baseline_ranges.txt", "w") as f: - f.write("Baseline Metric Ranges (5th-95th percentile)\n") - f.write("=" * 55 + "\n\n") - for metric, (low, high) in sorted(ranges.items()): - f.write(f"{metric:30s}: [{low:8.4f}, {high:8.4f}]\n") - - return output_dir diff --git a/stain_normalization/callbacks/__init__.py b/stain_normalization/callbacks/__init__.py index 09f4235..07eb497 100644 --- a/stain_normalization/callbacks/__init__.py +++ b/stain_normalization/callbacks/__init__.py @@ -1,7 +1,7 @@ -from stain_normalization.callbacks._base import DenormalizationCallback +from stain_normalization.callbacks._base import ImageCallback from stain_normalization.callbacks.analysis_export import AnalysisExport from stain_normalization.callbacks.tiles_export import TilesExport from stain_normalization.callbacks.wsi_assembler import WSIAssembler -__all__ = ["AnalysisExport", "DenormalizationCallback", "TilesExport", "WSIAssembler"] +__all__ = ["AnalysisExport", "ImageCallback", "TilesExport", "WSIAssembler"] diff --git a/stain_normalization/callbacks/_base.py b/stain_normalization/callbacks/_base.py index ce24a6e..65c21d2 100644 --- a/stain_normalization/callbacks/_base.py +++ b/stain_normalization/callbacks/_base.py @@ -3,30 +3,15 @@ import numpy as np import torch from lightning import Callback -from omegaconf import DictConfig -class DenormalizationCallback(Callback): - """Base callback providing denormalization helpers for model outputs.""" +class ImageCallback(Callback): + """Base callback providing tensor-to-image conversion. - def __init__(self, normalization_config: DictConfig) -> None: - super().__init__() - self.mean = torch.tensor(normalization_config.mean).view(3, 1, 1) - self.std = torch.tensor(normalization_config.std).view(3, 1, 1) + Expects denormalized [0,1] tensors (denormalization is done in the model). + """ - def denormalize(self, tensor: torch.Tensor) -> torch.Tensor: - """Reverse normalization: tensor → [0, 1] float.""" - device = tensor.device - return (tensor * self.std.to(device)) + self.mean.to(device) - - def tensor_to_image(self, tensor: torch.Tensor) -> np.ndarray[Any, Any]: - """Convert model output tensor to uint8 HWC numpy array.""" - return ( - self.denormalize(tensor) - .clamp(0, 1) - .mul(255) - .byte() - .permute(1, 2, 0) - .cpu() - .numpy() - ) + @staticmethod + def tensor_to_image(tensor: torch.Tensor) -> np.ndarray[Any, Any]: + """Convert [0,1] CHW tensor to uint8 HWC numpy array.""" + return tensor.mul(255).byte().permute(1, 2, 0).cpu().numpy() diff --git a/stain_normalization/callbacks/analysis_export.py b/stain_normalization/callbacks/analysis_export.py deleted file mode 100644 index 52ccc46..0000000 --- a/stain_normalization/callbacks/analysis_export.py +++ /dev/null @@ -1,59 +0,0 @@ -from pathlib import Path -from typing import Any - -import mlflow -import torch -from lightning import LightningModule, Trainer -from omegaconf import DictConfig - -from stain_normalization.analysis.analyzer import StainAnalyzer -from stain_normalization.callbacks._base import DenormalizationCallback -from stain_normalization.type_aliases import Outputs - - -class AnalysisExport(DenormalizationCallback): - """Exports analysis metrics during testing.""" - - def __init__( - self, output_dir: str | Path, normalization_config: DictConfig - ) -> None: - super().__init__(normalization_config) - self.output_dir = Path(output_dir) - self.output_dir.mkdir(parents=True, exist_ok=True) - - self.mod_analyzer = StainAnalyzer() - self.pred_analyzer = StainAnalyzer() - - def on_test_batch_end( # type: ignore[override] # narrowed Lightning STEP_OUTPUT - self, - trainer: Trainer, - pl_module: LightningModule, - outputs: Outputs, - batch: tuple[torch.Tensor, list[dict[str, Any]]], - batch_idx: int, - dataloader_idx: int = 0, - ) -> None: - """Computes metrics for each sample and accumulates results.""" - for b in range(len(outputs)): - original_img = batch[1][b]["original_image"].astype("uint8") - modified_img = (batch[1][b]["modified_image"] * 255).astype("uint8") - predicted_img = self.tensor_to_image(outputs[b]) - - self.mod_analyzer.compare(modified_img, paired_image=original_img) - self.pred_analyzer.compare(predicted_img, paired_image=original_img) - - def on_test_end( - self, - trainer: Trainer, - pl_module: LightningModule, - ) -> None: - """Saves collected metrics as CSV files and logs them as mlflow artifacts.""" - metrics_dir = self.output_dir / "analysis_metrics" - - mod_dir = self.mod_analyzer.save_csv(metrics_dir / "modified") - pred_dir = self.pred_analyzer.save_csv(metrics_dir / "predicted") - - for f in mod_dir.glob("*"): - mlflow.log_artifact(str(f), artifact_path="analysis_metrics/modified") - for f in pred_dir.glob("*"): - mlflow.log_artifact(str(f), artifact_path="analysis_metrics/predicted") diff --git a/stain_normalization/callbacks/tiles_export.py b/stain_normalization/callbacks/tiles_export.py index 8e3dfee..37ed261 100644 --- a/stain_normalization/callbacks/tiles_export.py +++ b/stain_normalization/callbacks/tiles_export.py @@ -3,22 +3,20 @@ import torch from lightning import LightningModule, Trainer -from omegaconf import DictConfig from PIL import Image -from stain_normalization.callbacks._base import DenormalizationCallback +from stain_normalization.callbacks._base import ImageCallback from stain_normalization.type_aliases import Outputs -class TilesExport(DenormalizationCallback): +class TilesExport(ImageCallback): def __init__( self, output_dir: str | Path, - normalization_config: DictConfig, n_first: int = 10, sample_rate: float = 0.0005, ) -> None: - super().__init__(normalization_config) + super().__init__() self.output_dir = Path(output_dir) self.output_dir.mkdir(parents=True, exist_ok=True) self.n_first = n_first diff --git a/stain_normalization/callbacks/wsi_assembler.py b/stain_normalization/callbacks/wsi_assembler.py index 677bfe7..1271080 100644 --- a/stain_normalization/callbacks/wsi_assembler.py +++ b/stain_normalization/callbacks/wsi_assembler.py @@ -7,10 +7,10 @@ import numpy as np import torch from lightning import LightningModule, Trainer -from omegaconf import DictConfig + from rationai.mlkit.lightning.callbacks import MultiloaderLifecycle -from stain_normalization.callbacks._base import DenormalizationCallback +from stain_normalization.callbacks._base import ImageCallback from stain_normalization.type_aliases import Outputs @@ -34,7 +34,7 @@ class _SlideBuffers: count_buffer: np.memmap[Any, Any] -class WSIAssembler(DenormalizationCallback, MultiloaderLifecycle): +class WSIAssembler(ImageCallback, MultiloaderLifecycle): """Assembles predicted tiles back into whole-slide pyramid TIFFs. Uses one dataloader per slide (via MultiloaderLifecycle) — buffers are @@ -44,10 +44,9 @@ class WSIAssembler(DenormalizationCallback, MultiloaderLifecycle): def __init__( self, output_dir: str | Path, - normalization_config: DictConfig, temp_dir: str | Path | None = None, ) -> None: - DenormalizationCallback.__init__(self, normalization_config) + ImageCallback.__init__(self) MultiloaderLifecycle.__init__(self) self.output_dir = Path(output_dir) self.temp_dir = str(temp_dir) if temp_dir else None diff --git a/stain_normalization/data/data_module.py b/stain_normalization/data/data_module.py index 2ab8f3d..2693f1d 100644 --- a/stain_normalization/data/data_module.py +++ b/stain_normalization/data/data_module.py @@ -54,16 +54,13 @@ def val_dataloader(self) -> Iterable[Batch]: persistent_workers=self.num_workers > 0, ) - def test_dataloader(self) -> list[DataLoader[PredictBatch]]: - return [ - DataLoader( - dataset, - batch_size=self.batch_size, - num_workers=self.num_workers, - collate_fn=collate_fn, - ) - for dataset in self.test.datasets - ] + def test_dataloader(self) -> DataLoader[PredictBatch]: + return DataLoader( + self.test, + batch_size=self.batch_size, + num_workers=self.num_workers, + collate_fn=collate_fn, + ) def predict_dataloader(self) -> list[DataLoader[PredictBatch]]: return [ diff --git a/stain_normalization/metrics/torch_metrics.py b/stain_normalization/metrics/torch_metrics.py index d541b88..48d0402 100644 --- a/stain_normalization/metrics/torch_metrics.py +++ b/stain_normalization/metrics/torch_metrics.py @@ -77,7 +77,7 @@ def __init__(self) -> None: self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: - lab = rgb_to_lab(preds.clamp(0, 1)) + lab = rgb_to_lab(preds) self.brightness_sum += lab[:, 0].mean() self.count += 1 @@ -103,11 +103,11 @@ def __init__(self) -> None: self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: - pred_lab = rgb_to_lab(preds.clamp(0, 1)) - target_lab = rgb_to_lab(target.clamp(0, 1)) + pred_lab = rgb_to_lab(preds) + target_lab = rgb_to_lab(target) - pred_l = pred_lab[:, 0:1] - target_l = target_lab[:, 0:1] + pred_l = pred_lab[:, :1] + target_l = target_lab[:, :1] self.psnr_sum += peak_signal_noise_ratio(pred_l, target_l, data_range=100.0) self.count += 1 @@ -133,16 +133,16 @@ def __init__(self) -> None: self.add_state("count", default=torch.tensor(0), dist_reduce_fx="sum") def update(self, preds: Tensor, target: Tensor) -> None: - for i in range(preds.shape[0]): - x = preds[i].flatten().float() - y = target[i].flatten().float() - - if x.std() == 0 or y.std() == 0: - continue - - pcc = torch.corrcoef(torch.stack([x, y]))[0, 1] - self.pcc_sum += pcc - self.count += 1 + x = preds.flatten(1).float() + y = target.flatten(1).float() + mean_x = x.mean(dim=1, keepdim=True) + mean_y = y.mean(dim=1, keepdim=True) + dx, dy = x - mean_x, y - mean_y + num = (dx * dy).sum(dim=1) + den = dx.norm(dim=1) * dy.norm(dim=1) + valid = den > 0 + self.pcc_sum += (num[valid] / den[valid]).sum() + self.count += valid.sum() def compute(self) -> Tensor: if self.count == 0: diff --git a/stain_normalization/stain_normalization_model.py b/stain_normalization/stain_normalization_model.py index ff51b98..0c61a31 100644 --- a/stain_normalization/stain_normalization_model.py +++ b/stain_normalization/stain_normalization_model.py @@ -21,13 +21,13 @@ class StainNormalizationModel(LightningModule): def __init__( self, + normalize_mean: list[float], + normalize_std: list[float], lr: float = 1e-4, lambda_dssim: float = 0.6, lambda_l1: float = 0.2, lambda_lum: float = 0.2, lambda_gdl: float = 0.1, - normalize_mean: list[float] | None = None, - normalize_std: list[float] | None = None, ) -> None: super().__init__() self.lr = lr @@ -39,16 +39,12 @@ def __init__( lambda_gdl=lambda_gdl, ) - if normalize_mean is not None and normalize_std is not None: - self.register_buffer( - "_denorm_mean", torch.tensor(normalize_mean).view(1, 3, 1, 1) - ) - self.register_buffer( - "_denorm_std", torch.tensor(normalize_std).view(1, 3, 1, 1) - ) - else: - self.register_buffer("_denorm_mean", None) - self.register_buffer("_denorm_std", None) + self.register_buffer( + "_denorm_mean", torch.tensor(normalize_mean).view(1, 3, 1, 1) + ) + self.register_buffer( + "_denorm_std", torch.tensor(normalize_std).view(1, 3, 1, 1) + ) val_metrics = MetricCollection( {"ssim": StructuralSimilarityIndexMeasure(), "l1": MeanAbsoluteError()} @@ -71,11 +67,7 @@ def forward(self, x: Tensor) -> Outputs: return self.unet(x) def _denormalize(self, tensor: Tensor) -> Tensor: - if self._denorm_mean is None: - return tensor - mean: Tensor = self._denorm_mean # type: ignore[assignment] - std: Tensor = self._denorm_std # type: ignore[assignment] - return tensor * std + mean + return tensor * self._denorm_std + self._denorm_mean def training_step(self, batch: Batch) -> Tensor: inputs, targets = batch @@ -99,29 +91,27 @@ def validation_step(self, batch: Batch) -> None: on_epoch=True, ) - def test_step( - self, batch: PredictBatch, batch_idx: int = 0, dataloader_idx: int = 0 - ) -> Outputs: + def test_step(self, batch: PredictBatch, batch_idx: int = 0) -> Outputs: inputs, data = batch outputs = self(inputs) targets = stack([item["original_image_tensor"] for item in data]).to( outputs.device ) - denormed_outputs = self._denormalize(outputs) - denormed_targets = self._denormalize(targets) + denormed_outputs = self._denormalize(outputs).clamp(0, 1) + denormed_targets = self._denormalize(targets).clamp(0, 1) self.test_metrics.update(denormed_outputs, denormed_targets) self.log_dict( self.test_metrics, batch_size=len(inputs), on_epoch=True, ) - return outputs + return denormed_outputs def predict_step( self, batch: PredictBatch, batch_idx: int = 0, dataloader_idx: int = 0 ) -> Outputs: inputs = batch[0] - return self(inputs) + return self._denormalize(self(inputs)).clamp(0, 1) def configure_optimizers(self) -> Optimizer: return Adam(self.parameters(), lr=self.lr) From 3674c9dc0d1f032ea955968eeea9f54ce663087b Mon Sep 17 00:00:00 2001 From: Adam Lopatka <524733@mail.muni.cz> Date: Fri, 27 Mar 2026 02:38:00 +0100 Subject: [PATCH 13/13] fix: mypy fix --- stain_normalization/stain_normalization_model.py | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/stain_normalization/stain_normalization_model.py b/stain_normalization/stain_normalization_model.py index 0c61a31..015268e 100644 --- a/stain_normalization/stain_normalization_model.py +++ b/stain_normalization/stain_normalization_model.py @@ -67,7 +67,9 @@ def forward(self, x: Tensor) -> Outputs: return self.unet(x) def _denormalize(self, tensor: Tensor) -> Tensor: - return tensor * self._denorm_std + self._denorm_mean + std: Tensor = self._denorm_std # type: ignore[assignment] + mean: Tensor = self._denorm_mean # type: ignore[assignment] + return tensor * std + mean def training_step(self, batch: Batch) -> Tensor: inputs, targets = batch