We're at the point where this Open Chemistry Networks project would benefit from some simple, well-defined molecule synthesis from the community.
ABHD2 is a protein thought by many to be an important target for the development of new contraceptives, specifically non-hormonal ones. The SGC received a grant from the Gates Foundation to get this going. We've been working on it a while, and we're starting to think that in fact it's not a relevant target. You can read about the whole fascinating story on the wiki.
In short: We've developed some very simple and quite potent inhibitors of ABHD2. They're not quite good enough to be considered "chemical probes" and we could really do with improving the potency. Luckily they are very easy to synthesise. YOU can get involved. Are you a PhD student writing up? A Masters student looking for a cool project? A uni lab class manager looking for a fun project for a cohort of students to tackle in the lab? You can see the chemistry involved here, and we've suggested some targets. If you make them, we'll test them. If you're interested, please reach out to me or to Eve Carter, the current project champ.
This has been posted on LinkedIn and X. To cut to the chase, go here.
What if you're not lab based? Though this project has been running for nearly a couple of years, we need a Sir James Murray Student Champion - someone to keep things ticking over and to maintain this website. To date this role has been managed by @EveCarter but she now needs to focus on a couple of other projects. If you'd like to help out, contact us either by signing up to Github and posting something or by emailing chemistry@thesgc.org or Eve or Mat.
We're at the point where this Open Chemistry Networks project would benefit from some simple, well-defined molecule synthesis from the community.
ABHD2 is a protein thought by many to be an important target for the development of new contraceptives, specifically non-hormonal ones. The SGC received a grant from the Gates Foundation to get this going. We've been working on it a while, and we're starting to think that in fact it's not a relevant target. You can read about the whole fascinating story on the wiki.
In short: We've developed some very simple and quite potent inhibitors of ABHD2. They're not quite good enough to be considered "chemical probes" and we could really do with improving the potency. Luckily they are very easy to synthesise. YOU can get involved. Are you a PhD student writing up? A Masters student looking for a cool project? A uni lab class manager looking for a fun project for a cohort of students to tackle in the lab? You can see the chemistry involved here, and we've suggested some targets. If you make them, we'll test them. If you're interested, please reach out to me or to Eve Carter, the current project champ.
This has been posted on LinkedIn and X. To cut to the chase, go here.
What if you're not lab based? Though this project has been running for nearly a couple of years, we need a Sir James Murray Student Champion - someone to keep things ticking over and to maintain this website. To date this role has been managed by @EveCarter but she now needs to focus on a couple of other projects. If you'd like to help out, contact us either by signing up to Github and posting something or by emailing chemistry@thesgc.org or Eve or Mat.