diff --git a/mflags.go b/mflags.go
index ef2e814..d5a9c2f 100644
--- a/mflags.go
+++ b/mflags.go
@@ -1614,6 +1614,95 @@ func getTagValues(tag reflect.StructTag, key string) []string {
 	return values
 }
 
+// knownTags is the set of struct tag keys that FromStruct knows how to handle.
+// Keep this in sync with the Tag.Get() and getTagValues() calls in FromStruct.
+var knownTags = map[string]bool{
+	"long":        true,
+	"short":       true,
+	"default":     true,
+	"usage":       true,
+	"description": true,
+	"choice":      true,
+	"position":    true,
+	"rest":        true,
+	"unknown":     true,
+	"group":       true,
+}
+
+// validateStructTags checks that every struct tag on exported fields is one
+// that FromStruct actually reads. It returns an error listing all unrecognized
+// tags so the caller can fix them all in one pass.
+func validateStructTags(rt reflect.Type) error {
+	var errs []string
+	for i := 0; i < rt.NumField(); i++ {
+		field := rt.Field(i)
+
+		// Skip the blank identifier used for group declarations
+		if field.Name == "_" {
+			continue
+		}
+
+		if !field.IsExported() {
+			continue
+		}
+
+		// Recurse into embedded structs
+		ft := field.Type
+		if ft.Kind() == reflect.Ptr {
+			ft = ft.Elem()
+		}
+		if field.Anonymous && ft.Kind() == reflect.Struct {
+			if err := validateStructTags(ft); err != nil {
+				errs = append(errs, err.Error())
+			}
+			continue
+		}
+
+		// Parse the raw tag string into key:"value" pairs and check each key
+		tagStr := string(field.Tag)
+		for tagStr != "" {
+			// Skip leading spaces
+			tagStr = strings.TrimLeft(tagStr, " ")
+			if tagStr == "" {
+				break
+			}
+
+			// Find the key (everything before the colon)
+			colon := strings.Index(tagStr, ":")
+			if colon < 0 {
+				break
+			}
+			key := tagStr[:colon]
+			tagStr = tagStr[colon+1:]
+
+			// Skip past the quoted value
+			if len(tagStr) == 0 || tagStr[0] != '"' {
+				break
+			}
+			end := 1
+			for end < len(tagStr) && tagStr[end] != '"' {
+				if tagStr[end] == '\\' && end+1 < len(tagStr) {
+					end += 2
+				} else {
+					end++
+				}
+			}
+			if end >= len(tagStr) {
+				break
+			}
+			tagStr = tagStr[end+1:]
+
+			if !knownTags[key] {
+				errs = append(errs, fmt.Sprintf("unknown struct tag %q on field %s in %s", key, field.Name, rt.Name()))
+			}
+		}
+	}
+	if len(errs) > 0 {
+		return fmt.Errorf("invalid struct tags:\n  %s", strings.Join(errs, "\n  "))
+	}
+	return nil
+}
+
 // setFieldValue sets a string value to a reflect.Value based on its type
 func setFieldValue(fieldValue reflect.Value, value string) error {
 	switch fieldValue.Kind() {
@@ -1712,6 +1801,11 @@ func (f *FlagSet) FromStruct(v any, opts ...FromStructOption) error {
 
 	rt := rv.Type()
 
+	// Validate that all struct tags are ones we know how to handle
+	if err := validateStructTags(rt); err != nil {
+		return err
+	}
+
 	// First pass: check for self-declared group via `_ struct{} \`group:"..."\``
 	for i := 0; i < rt.NumField(); i++ {
 		field := rt.Field(i)
diff --git a/mflags_test.go b/mflags_test.go
index dc11738..de58a33 100644
--- a/mflags_test.go
+++ b/mflags_test.go
@@ -859,6 +859,90 @@ func TestFromStructErrors(t *testing.T) {
 	assert.Contains(t, err.Error(), "pointer to a struct")
 }
 
+func TestFromStructRejectsUnknownTags(t *testing.T) {
+	t.Run("single unknown tag", func(t *testing.T) {
+		type Opts struct {
+			Args struct{} `positional-args:"yes"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Opts{})
+		assert.Error(t, err)
+		assert.Contains(t, err.Error(), `unknown struct tag "positional-args"`)
+		assert.Contains(t, err.Error(), "Args")
+	})
+
+	t.Run("multiple unknown tags across fields", func(t *testing.T) {
+		type Opts struct {
+			Name string `long:"name" env:"MY_NAME"`
+			Port int    `long:"port" required:"true"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Opts{})
+		assert.Error(t, err)
+		assert.Contains(t, err.Error(), `"env"`)
+		assert.Contains(t, err.Error(), `"required"`)
+	})
+
+	t.Run("non-mflags tag like json", func(t *testing.T) {
+		type Opts struct {
+			Name string `json:"name"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Opts{})
+		assert.Error(t, err)
+		assert.Contains(t, err.Error(), `"json"`)
+	})
+
+	t.Run("embedded struct with unknown tags", func(t *testing.T) {
+		type Inner struct {
+			Addr string `long:"addr" yaml:"addr"`
+		}
+		type Outer struct {
+			Inner
+			Verbose bool `long:"verbose"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Outer{})
+		assert.Error(t, err)
+		assert.Contains(t, err.Error(), `"yaml"`)
+		assert.Contains(t, err.Error(), "Addr")
+	})
+
+	t.Run("unexported fields with arbitrary tags are ignored", func(t *testing.T) {
+		type Opts struct {
+			Verbose  bool   `long:"verbose"`
+			internal string `json:"internal" xml:"internal"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Opts{})
+		assert.NoError(t, err)
+	})
+
+	t.Run("valid tags pass", func(t *testing.T) {
+		type Opts struct {
+			Name    string   `long:"name" short:"n" default:"world" description:"Your name"`
+			Verbose bool     `long:"verbose" usage:"Enable verbose"`
+			Env     string   `long:"env" choice:"dev" choice:"prod"`
+			File    string   `position:"0"`
+			Rest    []string `rest:"true"`
+			Unknown []string `unknown:"true"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Opts{})
+		assert.NoError(t, err)
+	})
+
+	t.Run("group tag on blank field is allowed", func(t *testing.T) {
+		type Opts struct {
+			_       struct{} `group:"Server Options"`
+			Verbose bool     `long:"verbose"`
+		}
+		fs := NewFlagSet("test")
+		err := fs.FromStruct(&Opts{})
+		assert.NoError(t, err)
+	})
+}
+
 type CombinedUsageConfig struct {
 	Verbose bool          `long:"verbose" short:"v"`
 	Files   []string      `long:"files" short:"f"`