diff --git a/doc/api/quic.md b/doc/api/quic.md
index a19ff2befb5731..23dca30ae81b21 100644
--- a/doc/api/quic.md
+++ b/doc/api/quic.md
@@ -137,8 +137,12 @@ To avoid this, servers should use compact certificate chains:
   large RSA intermediates. The choice of CA directly affects handshake latency.
 
 Certificate compression ([RFC 8879][]) can also address this issue by
-compressing the certificate chain during the handshake. However, Node.js does
-not currently support TLS certificate compression.
+compressing the certificate chain during the handshake, often keeping the
+server's Certificate message within the amplification limit and avoiding the
+extra round trip. Certificate compression is opt-in via the
+[`certificateCompression`][] TLS option and is disabled by default. When
+enabled, it applies to both the server's certificate and, for mutual TLS,
+the client's certificate.
 
 ### Rate limiting
 
@@ -2918,6 +2922,34 @@ added: v23.8.0
 The TLS certificates to use for client sessions. For server sessions,
 certificates are specified per-identity in the [`sessionOptions.sni`][] map.
 
+#### `sessionOptions.certificateCompression`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+* Type: {string\[]} One or more of `'zlib'`, `'brotli'`, or `'zstd'`, in
+  preference order.
+
+Enables TLS certificate compression ([RFC 8879][]) for this session. When
+omitted, certificate compression is disabled.
+
+On the server side, the certificate chain is compressed using the first
+listed algorithm that the client advertises support for. On the client side,
+the listed algorithms are advertised to the server so that the server may
+compress its certificate. When client authentication is in use, the option
+also controls compression of the client's certificate.
+
+Compressing the certificate chain is especially useful for QUIC because it
+reduces the size of the server's first flight, which is bounded by the
+anti-amplification limit (see [Certificate size and handshake
+performance][]). Certificate compression requires TLS 1.3, which QUIC always
+uses.
+
+At most three algorithms may be specified. The option is silently ignored if
+Node.js was built against a shared OpenSSL that lacks certificate compression
+support.
+
 #### `sessionOptions.ciphers`
 
 <!-- YAML
@@ -4427,6 +4459,7 @@ throughput issues caused by flow control.
 
 [Aborting a stream]: #aborting-a-stream
 [Callback error handling]: #callback-error-handling
+[Certificate size and handshake performance]: #certificate-size-and-handshake-performance
 [JSON-SEQ]: https://www.rfc-editor.org/rfc/rfc7464
 [NSS Key Log Format]: https://udn.realityripple.com/docs/Mozilla/Projects/NSS/Key_Log_Format
 [Permission Model]: permissions.md#permission-model
@@ -4456,6 +4489,7 @@ throughput issues caused by flow control.
 [`application.enableConnectProtocol`]: #sessionoptionsapplication
 [`application.enableDatagrams`]: #sessionoptionsapplication
 [`application.qpackMaxDTableCapacity`]: #sessionoptionsapplication
+[`certificateCompression`]: #sessionoptionscertificatecompression
 [`crypto.X509Certificate`]: crypto.md#class-x509certificate
 [`endpoint.busy`]: #endpointbusy
 [`endpoint.maxConnectionsPerHost`]: #endpointmaxconnectionsperhost
diff --git a/lib/internal/quic/quic.js b/lib/internal/quic/quic.js
index 96362355c1deba..7849da1ae6c3cd 100644
--- a/lib/internal/quic/quic.js
+++ b/lib/internal/quic/quic.js
@@ -404,6 +404,9 @@ const endpointRegistry = new SafeSet();
  *   of protocol names in preference order.
  * @property {string} [ciphers] The TLS ciphers
  * @property {string} [groups] The TLS key-exchange groups
+ * @property {Array<'zlib'|'brotli'|'zstd'>} [certificateCompression] The
+ *   TLS certificate compression algorithms to enable (RFC 8879), in
+ *   preference order. Certificate compression is disabled when omitted.
  * @property {boolean} [keylog] Enable TLS key logging
  * @property {boolean} [verifyClient] Verify the client certificate (server only)
  * @property {boolean} [tlsTrace] Enable TLS tracing
@@ -4938,6 +4941,7 @@ function processTlsOptions(tls, forServer) {
     rejectUnauthorized = true,
     enableEarlyData = true,
     tlsTrace = false,
+    certificateCompression,
     sni,
     // Client-only: identity options are specified directly (no sni map)
     keys,
@@ -4962,6 +4966,43 @@ function processTlsOptions(tls, forServer) {
   validateBoolean(enableEarlyData, 'options.enableEarlyData');
   validateBoolean(tlsTrace, 'options.tlsTrace');
 
+  // Encode the certificate compression (RFC 8879) preference. The list of
+  // algorithm names is packed into a single Uint32 for a cheap JS->C++
+  // crossing, matching the encoding used by the node:tls implementation:
+  //   bits  0-7 : number of algorithms (1..3)
+  //   bits  8-15: algorithm id at position 0
+  //   bits 16-23: algorithm id at position 1
+  //   bits 24-31: algorithm id at position 2
+  // IDs match OpenSSL's TLSEXT_comp_cert_zlib (1), _brotli (2), _zstd (3).
+  // A value of 0 (the default) leaves certificate compression disabled.
+  let packedCertificateCompression = 0;
+  if (certificateCompression !== undefined) {
+    if (!ArrayIsArray(certificateCompression)) {
+      throw new ERR_INVALID_ARG_TYPE('options.certificateCompression',
+                                     'Array', certificateCompression);
+    }
+    if (certificateCompression.length > 3) {
+      throw new ERR_INVALID_ARG_VALUE('options.certificateCompression',
+                                      certificateCompression,
+                                      'can specify at most 3 algorithms');
+    }
+    let packed = certificateCompression.length;
+    for (let i = 0; i < certificateCompression.length; i++) {
+      const algoName = certificateCompression[i];
+      let id;
+      if (algoName === 'zlib') id = 1;
+      else if (algoName === 'brotli') id = 2;
+      else if (algoName === 'zstd') id = 3;
+      else {
+        throw new ERR_INVALID_ARG_VALUE(
+          `options.certificateCompression[${i}]`, algoName,
+          "must be 'zlib', 'brotli', or 'zstd'");
+      }
+      packed |= id << (8 * (i + 1));
+    }
+    packedCertificateCompression = packed;
+  }
+
   // Encode the ALPN option to wire format (length-prefixed protocol names).
   // Server: array of protocol names. Client: single protocol name.
   // If not specified, the C++ default (h3) is used.
@@ -5027,6 +5068,7 @@ function processTlsOptions(tls, forServer) {
     rejectUnauthorized,
     enableEarlyData,
     tlsTrace,
+    certificateCompression: packedCertificateCompression,
     ca,
     crl,
   };
diff --git a/src/quic/bindingdata.h b/src/quic/bindingdata.h
index 7879220e02b482..bd1b1d71393613 100644
--- a/src/quic/bindingdata.h
+++ b/src/quic/bindingdata.h
@@ -77,6 +77,7 @@ class SessionManager;
   V(bbr, "bbr")                                                                \
   V(ca, "ca")                                                                  \
   V(cc_algorithm, "cc")                                                        \
+  V(certificate_compression, "certificateCompression")                         \
   V(certs, "certs")                                                            \
   V(code, "code")                                                              \
   V(ciphers, "ciphers")                                                        \
diff --git a/src/quic/tlscontext.cc b/src/quic/tlscontext.cc
index c0a1610540ed3a..c669f767e71a45 100644
--- a/src/quic/tlscontext.cc
+++ b/src/quic/tlscontext.cc
@@ -12,6 +12,9 @@
 #include <ngtcp2/ngtcp2_crypto_ossl.h>
 #include <node_sockaddr-inl.h>
 #include <openssl/ssl.h>
+#ifdef NODE_OPENSSL_HAS_CERT_COMP
+#include <openssl/comp.h>
+#endif
 #include <util-inl.h>
 #include <v8.h>
 #include "application.h"
@@ -594,6 +597,48 @@ SSLCtxPointer TLSContext::Initialize(Environment* env) {
     }
   }
 
+  // TLS certificate compression (RFC 8879). OpenSSL enables all available
+  // algorithms by default once compression libraries are linked, so we
+  // always clear the preference first to keep certificate compression
+  // opt-in (matching the behavior of node:tls). When the
+  // certificateCompression option is set, apply the requested algorithms
+  // and pre-compress the certificate(s) loaded above. QUIC always uses
+  // TLS 1.3, which is the minimum required for certificate compression.
+#ifdef NODE_OPENSSL_HAS_CERT_COMP
+  {
+    ClearErrorOnReturn clear_error_on_return;
+    SSL_CTX_set1_cert_comp_preference(ctx.get(), nullptr, 0);
+
+    // The JS layer packs (length | alg0<<8 | alg1<<16 | alg2<<24) into a
+    // single uint32. IDs match TLSEXT_comp_cert_zlib (1), _brotli (2),
+    // _zstd (3).
+    const uint32_t packed = options_.certificate_compression;
+    const size_t len = packed & 0xff;
+    if (len > 0) {
+      // TLSEXT_comp_cert_limit bounds the zero-terminated algs array; the
+      // number of usable algorithms is one fewer.
+      constexpr size_t kMaxCompAlgs = TLSEXT_comp_cert_limit - 1;
+      if (len > kMaxCompAlgs) {
+        validation_error_ = "Invalid certificate compression preference";
+        return SSLCtxPointer();
+      }
+      int algs[kMaxCompAlgs];
+      for (size_t i = 0; i < len; i++) {
+        algs[i] = (packed >> (8 * (i + 1))) & 0xff;
+      }
+      if (!SSL_CTX_set1_cert_comp_preference(ctx.get(), algs, len)) {
+        validation_error_ = "Failed to set certificate compression preference";
+        return SSLCtxPointer();
+      }
+      // Pre-compress the loaded certificate(s) for the preferred algorithms.
+      // Returns 0 when no certificate is loaded (e.g. a client context) or
+      // when compression did not reduce the size; both are non-fatal.
+      constexpr int kCompressAllAlgs = 0;
+      SSL_CTX_compress_certs(ctx.get(), kCompressAllAlgs);
+    }
+  }
+#endif  // NODE_OPENSSL_HAS_CERT_COMP
+
   {
     ClearErrorOnReturn clear_error_on_return;
     for (const auto& key : options_.keys) {
@@ -730,9 +775,9 @@ Maybe<TLSContext::Options> TLSContext::Options::From(Environment* env,
       !SET(enable_early_data) || !SET(enable_tls_trace) || !SET(alpn) ||
       !SET(servername) || !SET(ciphers) || !SET(groups) ||
       !SET(verify_private_key) || !SET(keylog) || !SET(port) ||
-      !SET(authoritative) || !SET_VECTOR(crypto::KeyObjectData, keys) ||
-      !SET_VECTOR(Store, certs) || !SET_VECTOR(Store, ca) ||
-      !SET_VECTOR(Store, crl)) {
+      !SET(certificate_compression) || !SET(authoritative) ||
+      !SET_VECTOR(crypto::KeyObjectData, keys) || !SET_VECTOR(Store, certs) ||
+      !SET_VECTOR(Store, ca) || !SET_VECTOR(Store, crl)) {
     return Nothing<Options>();
   }
 
@@ -761,6 +806,8 @@ std::string TLSContext::Options::ToString() const {
          (verify_private_key ? std::string("yes") : std::string("no"));
   res += prefix + "ciphers: " + ciphers;
   res += prefix + "groups: " + groups;
+  res += prefix +
+         "certificate compression: " + std::to_string(certificate_compression);
   res += prefix + "keys: " + std::to_string(keys.size());
   res += prefix + "certs: " + std::to_string(certs.size());
   res += prefix + "ca: " + std::to_string(ca.size());
diff --git a/src/quic/tlscontext.h b/src/quic/tlscontext.h
index ba502cf1f868df..f1d6451bcfa786 100644
--- a/src/quic/tlscontext.h
+++ b/src/quic/tlscontext.h
@@ -192,6 +192,16 @@ class TLSContext final : public MemoryRetainer,
     // The list of TLS groups to use for this session.
     std::string groups = DEFAULT_GROUPS;
 
+    // TLS certificate compression (RFC 8879) preference, packed by the JS
+    // layer as (length | alg0<<8 | alg1<<16 | alg2<<24). Algorithm IDs match
+    // OpenSSL's TLSEXT_comp_cert_zlib (1), _brotli (2), _zstd (3). A value of
+    // 0 means certificate compression is disabled (the default). Certificate
+    // compression is particularly valuable for QUIC because it reduces the
+    // size of the server's Certificate message, which is otherwise likely to
+    // exceed the anti-amplification limit and force an extra handshake round
+    // trip. JavaScript option name "certificateCompression".
+    uint32_t certificate_compression = 0;
+
     // When true, enables keylog output for the session.
     bool keylog = false;
 
diff --git a/test/parallel/test-quic-certificate-compression.mjs b/test/parallel/test-quic-certificate-compression.mjs
new file mode 100644
index 00000000000000..455029bfb648ed
--- /dev/null
+++ b/test/parallel/test-quic-certificate-compression.mjs
@@ -0,0 +1,112 @@
+// Flags: --experimental-quic --no-warnings
+
+import { hasQuic, skip, mustCall } from '../common/index.mjs';
+import assert from 'node:assert';
+import * as fixtures from '../common/fixtures.mjs';
+
+if (!hasQuic) {
+  skip('QUIC is not enabled');
+}
+
+const { listen, connect } = await import('node:quic');
+const { createPrivateKey } = await import('node:crypto');
+const tls = await import('node:tls');
+
+const key = createPrivateKey(fixtures.readKey('agent1-key.pem'));
+const cert = fixtures.readKey('agent1-cert.pem');
+
+// Certificate compression (RFC 8879) depends on the OpenSSL build linking in
+// the compression libraries. Reuse the node:tls detection helper to decide
+// whether the feature is available.
+const supported = tls.getCertificateCompressionAlgorithms();
+if (supported.length === 0) {
+  skip('certificate compression not supported by this OpenSSL build');
+}
+
+// ---------------------------------------------------------------------------
+// Option validation. The certificateCompression option is parsed by
+// processTlsOptions during connect()/listen(), so invalid values reject the
+// returned promise before any network activity happens.
+// ---------------------------------------------------------------------------
+{
+  // Non-array values are rejected.
+  await assert.rejects(
+    connect('127.0.0.1:4433', { certificateCompression: true }),
+    { code: 'ERR_INVALID_ARG_TYPE' });
+
+  await assert.rejects(
+    connect('127.0.0.1:4433', { certificateCompression: 'zlib' }),
+    { code: 'ERR_INVALID_ARG_TYPE' });
+
+  // Unknown algorithm names are rejected.
+  await assert.rejects(
+    connect('127.0.0.1:4433', { certificateCompression: ['invalid'] }),
+    { code: 'ERR_INVALID_ARG_VALUE',
+      message: /must be 'zlib', 'brotli', or 'zstd'/ });
+
+  // Non-string entries are rejected.
+  await assert.rejects(
+    connect('127.0.0.1:4433', { certificateCompression: [1] }),
+    { code: 'ERR_INVALID_ARG_VALUE',
+      message: /must be 'zlib', 'brotli', or 'zstd'/ });
+
+  // At most three algorithms may be specified.
+  await assert.rejects(
+    connect('127.0.0.1:4433', {
+      certificateCompression: ['zlib', 'brotli', 'zstd', 'zlib'],
+    }),
+    { code: 'ERR_INVALID_ARG_VALUE', message: /at most 3 algorithms/ });
+}
+
+// ---------------------------------------------------------------------------
+// Functional handshakes. Enabling certificate compression must not break the
+// TLS 1.3 handshake. The on-the-wire size reduction is exercised by the
+// node:tls certificate compression test; over QUIC the payload is encrypted
+// and carried in UDP datagrams, so here we assert the handshake completes
+// successfully with the option enabled on the server, the client, or both.
+// ---------------------------------------------------------------------------
+async function handshake({ serverAlgs, clientAlgs }) {
+  const serverOpened = Promise.withResolvers();
+
+  const endpoint = await listen(mustCall(async (serverSession) => {
+    const info = await serverSession.opened;
+    assert.strictEqual(info.protocol, 'h3');
+    serverOpened.resolve();
+    serverSession.close();
+  }), {
+    sni: { '*': { keys: [key], certs: [cert] } },
+    ...(serverAlgs !== undefined ?
+      { certificateCompression: serverAlgs } : {}),
+  });
+
+  const clientSession = await connect(endpoint.address, {
+    servername: 'localhost',
+    verifyPeer: 'manual',
+    ...(clientAlgs !== undefined ?
+      { certificateCompression: clientAlgs } : {}),
+  });
+
+  const info = await clientSession.opened;
+  assert.strictEqual(info.protocol, 'h3');
+
+  await serverOpened.promise;
+  await clientSession.close();
+  await endpoint.close();
+}
+
+// Each supported algorithm negotiates a successful handshake when enabled on
+// both peers.
+for (const algo of supported) {
+  await handshake({ serverAlgs: [algo], clientAlgs: [algo] });
+}
+
+// All supported algorithms advertised together.
+await handshake({ serverAlgs: supported, clientAlgs: supported });
+
+// Asymmetric configurations must also complete: a peer that does not advertise
+// compression simply receives an uncompressed certificate.
+await handshake({ serverAlgs: [supported[0]], clientAlgs: undefined });
+await handshake({ serverAlgs: undefined, clientAlgs: [supported[0]] });
+
+// An empty array is equivalent to disabling compression.
+await handshake({ serverAlgs: [], clientAlgs: [] });