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This is a lite version of the CellOracle package to run functions necessary to HuMMuS and ReCoN while increasing dependencies flexibility

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CellOracle-lite

Lightweight fork of CellOracle for ReCoN / HuMMuS

⚠️ Important notice
This repository is a lightweight fork of the original CellOracle project
(https://github.com/morris-lab/CellOracle).

It is not affiliated with, endorsed by, or maintained by the original CellOracle authors.


What is CellOracle-lite?

CellOracle-lite is a reduced version of CellOracle designed to support Gene Regulatory Network (GRN) workflows used in ReCoN and HuMMuS, while avoiding heavy dependencies required by the full CellOracle stack.

Version: 0.21.0 (lite fork)
Import as: import celloracle
Maintained by: cantinilab

This fork was created because some dependency combinations required by the full CellOracle package could not be resolved in the environments used by ReCoN and HuMMuS.

This fork:

  • keeps the core GRN-related functionality needed by ReCoN
  • removes optional or heavyweight components not required for these workflows
  • aims to be faster and easier to install in lightweight environments

If you need the full CellOracle feature set, please use the official CellOracle package instead.


Original project

CellOracle is a Python library for in silico gene perturbation analyses using single-cell omics data and Gene Regulatory Network models.

Original repository:
https://github.com/morris-lab/CellOracle

Original publication:
Dissecting cell identity via network inference and in silico gene perturbation
https://www.nature.com/articles/s41586-022-05688-9

Original documentation:
https://morris-lab.github.io/CellOracle.documentation/


License

This fork is distributed under the same license terms as the original CellOracle project.

⚠️ Non-commercial restriction applies
CellOracle (and therefore this fork) may be used for non-commercial academic research purposes only.
Commercial use requires permission from the original CellOracle authors.

See the LICENSE file for full details.


Questions, issues, and support

Please do not contact the original CellOracle maintainers about issues specific to this fork.


Supported species and reference genomes

(Same as upstream; unchanged)

  • Human: ['hg38', 'hg19']
  • Mouse: ['mm39', 'mm10', 'mm9']
  • S.cerevisiae: ["sacCer2", "sacCer3"]
  • Zebrafish: ["danRer7", "danRer10", "danRer11"]
  • Xenopus tropicalis: ["xenTro2", "xenTro3"]
  • Xenopus laevis: ["Xenopus_laevis_v10.1"]
  • Rat: ["rn4", "rn5", "rn6"]
  • Drosophila: ["dm3", "dm6"]
  • C.elegans: ["ce6", "ce10"]
  • Arabidopsis: ["TAIR10"]
  • Chicken: ["galGal4", "galGal5", "galGal6"]
  • Guinea Pig: ["Cavpor3.0"]
  • Pig: ["Sscrofa11.1"]

Changelog

For upstream changes, see:
https://morris-lab.github.io/CellOracle.documentation/changelog/index.html

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This is a lite version of the CellOracle package to run functions necessary to HuMMuS and ReCoN while increasing dependencies flexibility

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