immcantation/igphyml
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**IMPORTANT!** IgPhyML has moved to https://github.com/immcantation/igphyml To update Git configuration settings use: ``` git config user.email "your-gh-user@email.com" git config user.name "your-gh-user-name" git remote set-url origin git@github.com:immcantation/igphyml.git ``` IgPhyML - B cell phylogenetic inference package ================================================================================ IgPhyML is a program designed to build phylogenetic trees and test evolutionary hypotheses regarding B cell affinity maturation. The biology of B cell somatic hypermutation (SHM) violates important assumptions in most standard phylogenetic substitution models; further, while most phylogenetics programs are designed to analyze single lineages, B cell repertoires typically contain thousands of lineages. IgPhyML addresses both of these issues by implementing substitution models that correct for the context-sensitive nature of SHM, and combines information from multiple lineages to give more precisely estimated repertoire-wide model parameter estimates. IgPhyML is integrated into the Immcantation framework, meaning users can easily build and visualize B cell lineage trees and test hypotheses about mutation and selection in B cell repertoires.