Enzyme

Local-first knowledge indexing — explore your Obsidian vault by concept, not keyword.

Install

curl -fsSL https://raw.githubusercontent.com/jshph/enzyme/main/install.sh | bash
enzyme setup

On macOS you can also use Homebrew:

brew install jshph/enzyme/enzyme-cli
enzyme setup

Then add the Claude Code plugin:

claude marketplace add jshph/enzyme
claude plugin install enzyme

Quick start

cd /path/to/your/vault
enzyme init

Inside Claude Code, invoke /enzyme to explore your vault.

What it does

Your vault already has a shape. The tags you chose, the links you drew, the folders you sorted things into — those aren't just organization. They're evidence of how you've been thinking. Enzyme reads those signals, builds semantic clusters, and generates catalysts — thematic questions that surface content those tags alone would never find.

A search for "feeling stuck on the project" finds notes about creative blocks, momentum, and resistance — even if none of those words appear in the query or the notes.

Core concepts

• Entities — the tags, links, and folders you already use. Each one becomes a semantic cluster organized by how you think.
• Catalysts — compressed themes Enzyme discovers across your writing. They're the handles your vault has grown; searching through them connects you to content keyword matching won't find.
• Petri — a live view of what's trending and the catalysts anchored to each entity.

Requirements

• An Obsidian vault
• macOS (Apple Silicon or Intel) or Linux (x86_64 or aarch64)
• An OpenAI or OpenRouter API key for catalyst generation (OPENAI_API_KEY or OPENROUTER_API_KEY)

Links

• enzyme.garden
• enzyme-rust — source code