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2 changes: 1 addition & 1 deletion README.md
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Expand Up @@ -6,7 +6,7 @@ short-read sequence tags mapped to the genome using a binomial
distribution model. Regions flagged by the algorithm are called
"hotspots." The algorithm utilizes a local background model that
automatically normalizes for large regions of elevated tag levels due
to, for example, copy number effects. Hotpsot is otherwise able to
to, for example, copy number effects. Hotspot is otherwise able to
detect regions of enrichment of highly-variable size, making it
applicable to both broad and highly-punctate signals. We have applied
it extensively to DNase-seq and ChIP-seq data, including transcription
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